Evidence map›Paper›PMID 40250845›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Splenic modulation of the early inflammatory response to regional and global ischemia/reperfusion injury in swine.

Tyler J Rolland, Emily R Hudson, Luke A Graser, Sumbule Zahra, Daniel Cucinotta, Brian R Weil

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tyler J RollandDepartment of Physiology & Biophysics, State University of New York at Buffalo, Buffalo, New York, United States.ORCID 0000-0003-2700-8160
Emily R HudsonDepartment of Physiology & Biophysics, State University of New York at Buffalo, Buffalo, New York, United States.
Luke A GraserDepartment of Pharmacology & Toxicology, State University of New York at Buffalo, Buffalo, New York, United States.ORCID 0009-0008-6931-8224
Sumbule ZahraDepartment of Biological Sciences, State University of New York at Buffalo, Buffalo, New York, United States.
Daniel CucinottaDepartment of Biological Sciences, State University of New York at Buffalo, Buffalo, New York, United States.
Brian R WeilDepartment of Physiology & Biophysics, State University of New York at Buffalo, Buffalo, New York, United States.ORCID 0000-0002-8832-6771

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Immunomodulatory Therapy After Resuscitation From Cardiac ArrestR01HL160538 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Brian Raymond Weil · 2022 to 2026
$2.3M
American Heart Association (AHA) 24PRE1193924HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001412HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL160538NCATS NIH HHS UL1 TR001412NHLBI NIH HHS R01 HL160538
6 · The paper itself

Abstract

The spleen has been identified as a source of proinflammatory leukocytes mobilized after local ischemic injury in rodents. However, the role of the spleen in the inflammatory response to regional or global ischemia/reperfusion injury (IRI) in larger mammals is unknown. We investigated the spleen's contribution to early IRI-associated inflammation in porcine models of acute reperfused myocardial infarction (AMI) and sudden cardiac arrest (SCA). Swine were randomized to splenectomy (SPLX;

Indexed as

InflammationMyocardial InfarctionMyocardial Reperfusion InjurySpleenAnimalsCardiopulmonary ResuscitationCytokinesDisease Models, AnimalHeart ArrestHemodynamicsLeukocytesMaleSplenectomySwineTime FactorsVentricular FibrillationCytokinesinflammationleukocyte mobilizationmyocardial infarctionpostcardiac arrest syndromesudden cardiac arrest

Identifiers

PMID40250845
PMCPMC12173173

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.