Evidence map›Paper›PMID 40250698›Full record

ArticleCellular signalling2025

PKA restricts ERK signaling in learning and memory Kenyon cell neurons.

James C Sears, Kendal Broadie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James C SearsVanderbilt Brain Institute, Vanderbilt University and Medical Center, Nashville, TN 37235, USA; Department of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN 37235, USA.
Kendal BroadieVanderbilt Brain Institute, Vanderbilt University and Medical Center, Nashville, TN 37235, USA; Department of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN 37235, USA; Department of Cell and Developmental Biology, Vanderbilt University and Medical Center, Nashville, TN 37235, USA; Department of Pharmacology, Vanderbilt University and Medical Center, Nashville, TN 37235, USA; Vanderbilt Kennedy Center, Vanderbilt University and Medical Center, Nashville, TN 37235, USA. Electronic address: kendal.broadie@vanderbilt.edu.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
In Vivo Analyses of Kinase Signaling in Learning/Memory CircuitryR01NS131557 · NINDS · VANDERBILT UNIVERSITY · PI Kendal Broadie · 2024 to 2026
$1.2M
NICHD NIH HHS P50 HD103537NINDS NIH HHS R01 NS131557
6 · The paper itself

Abstract

Protein Kinase A (PKA) and Extracellular Signal-Regulated Kinase (ERK) have core roles in learning and memory. Here, we investigate kinase-kinase signaling interactions in the Drosophila brain Kenyon cell learning/memory circuit using separation of phases-based activity reporter of kinase (SPARK) biosensors to image circuit-localized functions in vivo. We find that constitutively active Rapidly Accelerated Fibrosarcoma (RAF

Indexed as

Cyclic AMP-Dependent Protein KinasesExtracellular Signal-Regulated MAP KinasesLearningMAP Kinase Signaling SystemMemoryNeuronsAnimalsDrosophila melanogasterDrosophila ProteinsCyclic AMP-Dependent Protein KinasesDrosophila ProteinsExtracellular Signal-Regulated MAP KinasesBrain circuitDrosophilaERKKinasePKARAFSeizure model

Identifiers

PMID40250698
PMCPMC12548963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.