Evidence map›Paper›PMID 40250444›Full record

ArticleCancer cell2025

Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation.

Mona Teng, Jiacheng Guo, Xin Xu, Xinpei Ci, Yulin Mo, Yakup Kohen, Zuyao Ni, Sujun Chen, Wang Yuan Guo, Martin Bakht and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  11. The Five-Decade Journey of Small Cell Lung Cancer.Cancer communications (London, England) · 2026
    Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Mona TengDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Jiacheng GuoShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Xin XuPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Xinpei CiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Yulin MoPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Yakup KohenDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Zuyao NiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Sujun ChenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Wang Yuan GuoPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Martin BakhtDivision of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
Shengyu KuDivision of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
Michael SigourosEnglander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
Wenqin LuoDepartment of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Colette Maya MacariosDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Ziting XiaDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada.
Moliang ChenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Sami Ul HaqPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Wen YangDepartment of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Alejandro BerlinPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Theo van der KwastPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Leigh EllisCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Amina ZoubeidiVancouver Prostate Centre, Vancouver, BC, Canada; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Gang ZhengPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jie MingDepartment of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuzhuo WangVancouver Prostate Centre, Vancouver, BC, Canada; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Haissi CuiDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Benjamin H LokDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Brian RaughtDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Himisha BeltranDivision of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA. Electronic address: himisha_beltran@dfci.harvard.edu.
Jun QinShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China. Electronic address: qinjun@sibs.ac.cn.
Housheng Hansen HeDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address: hansen.he@uhn.ca.

Funding

Tumor and Circulating Markers as Links Between Obesity and Lethal Prostate CanceP50CA090381 · NCI · DANA-FARBER CANCER INSTITUTE · PI KANTOFF, PHILIP W · 2002 to 2017
$36.2M
Molecular mechanisms underlying lineage plasticity in prostate cancerR37CA241486 · NCI · DANA-FARBER CANCER INST · PI Himisha Beltran · 2020 to 2026
$4.1M
ATR Dependency as a Novel Therapeutic Target in Lethal RB Deficient ProstateCancerR01CA252468 · NCI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI Leigh Ellis · 2020 to 2026
$1.5M
NCI NIH HHS P50 CA090381NCI NIH HHS R01 CA252468NCI NIH HHS R37 CA241486
6 · The paper itself

Abstract

Circular RNA (circRNA) is a class of noncoding RNA with regulatory potentials. Its role in the transdifferentiation of prostate and lung adenocarcinoma into neuroendocrine prostate cancer (NEPC) and small cell lung cancer (SCLC) remains unexplored. Here, we identified circRMST as an exceptionally abundant circRNA predominantly expressed in NEPC and SCLC, with strong conservation between humans and mice. Functional studies using shRNA, siRNA, CRISPR-Cas13, and Cas9 consistently demonstrate that circRMST is essential for tumor growth and the expression of ASCL1, a master regulator of neuroendocrine fate. Genetic knockout of Rmst in NEPC genetic engineered mouse models prevents neuroendocrine transdifferentiation, maintaining tumors in an adenocarcinoma state. Mechanistically, circRMST physically interacts with lineage transcription factors NKX2-1 and SOX2. Loss of circRMST induces NKX2-1 protein degradation through autophagy-lysosomal pathway and alters the genomic binding of SOX2, collectively leading to the loss of ASCL1 transcription.

Indexed as

Cell TransdifferentiationLung NeoplasmsNeuroendocrine TumorsProstatic NeoplasmsRNA, CircularThyroid Nuclear Factor 1Transcription FactorsAnimalsBasic Helix-Loop-Helix ProteinsCell LineageCell Line, TumorGene Expression Regulation, NeoplasticHumansMaleMiceMice, KnockoutASCL1 protein, humanBasic Helix-Loop-Helix ProteinsNKX2-1 protein, humanNkx2-1 protein, mouseRNA, CircularSOX2 protein, humanSOXB1 Transcription FactorsThyroid Nuclear Factor 1Transcription Factorscircular RNAlineage plasticityneuroedocrine prostate cancernoncoding RNARNA protein interactionssmall cell lung cancertranscription factors

Identifiers

PMID40250444
PMCPMC12991876

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.