Evidence map›Paper›PMID 40250439›Full record

ArticleStem cell reports2025

CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia.

Jinyuan Lu, Lixin Lv, Xiaoxue Tian, Zheng Li, Yuting Ma, Nannan Li, Jian Wang, Guangming Wang, Yu Zeng, Wenjun Zhang and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jinyuan LuTongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, P.R. China; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200333, P.R. China.
Lixin LvTongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, P.R. China; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200333, P.R. China.
Xiaoxue TianTongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, P.R. China; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200333, P.R. China.
Zheng LiDepartment of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Road, Shanghai 201112, P.R. China.
Yuting MaTongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, P.R. China; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200333, P.R. China.
Nannan LiTongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, P.R. China; Department of Hematology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200333, P.R. China.
Jian WangTongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, P.R. China; Stem Cell Research Center, East Hospital, Tongji University School of Medicine, Shanghai 200331, P.R. China.
Guangming WangStem Cell Research Center, East Hospital, Tongji University School of Medicine, Shanghai 200331, P.R. China.
Yu ZengDepartment of Hematology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200333, P.R. China.
Wenjun ZhangDepartment of Hematology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200333, P.R. China.
Jun XuStem Cell Research Center, East Hospital, Tongji University School of Medicine, Shanghai 200331, P.R. China.
Aibin LiangDepartment of Hematology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200333, P.R. China. Electronic address: lab7182@tongji.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukemic stem cells (LSCs) are a small subset of leukemia cells that drive leukemia initiation and maintenance. Herein, we report that CD37, a member of transmembrane 4 superfamily (TM4SF), regulates the survival of acute myeloid leukemia (AML) cells as well as the self-renewal of AML LSCs. The downregulation of CD37 retarded proliferation and increased apoptosis in human AML cell lines THP-1 and OCI-AML2. Deficiency of CD37 in vivo had a minimal effect on normal hematopoiesis but significantly impeded leukemia maintenance and propagation, which led to increased apoptosis and decreased cell cycle entry in AML blasts as well as impaired colony formation and declined frequency of AML LSCs in the serial transplantation. Furthermore, CD37 interacted with integrin α4β7 and activated the phosphatidylinositol 3-kinase (PI3K)-AKT pathway mediated by integrin signaling. Our study provides novel insights for targeted therapy of AML, indicating CD37 as a safe and effective target for immunotherapy.

Indexed as

Cell Self RenewalIntegrinsLeukemia, Myeloid, AcuteNeoplastic Stem CellsSignal TransductionTetraspaninsAnimalsApoptosisCell Line, TumorCell ProliferationHumansMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktIntegrinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTetraspaninsacute myeloid leukemiaCD37integrinleukemic stem celltetraspanin

Identifiers

PMID40250439
PMCPMC12143136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.