Evidence map›Paper›PMID 40250302›Full record

ReviewUltrasonics sonochemistry2025

Ultrasound-activated piezoelectric biomaterials for cartilage regeneration.

Yangchen Wei, Zhengyang Li, Tianjing Yu, Yan Chen, Qinglai Yang, Kaikai Wen, Junlin Liao, Linlin Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yangchen WeiThe First Affiliated Hospital, Center of Burn & Plastic and Wound Repair, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China; Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, PR China.
Zhengyang LiThe First Affiliated Hospital, Center of Burn & Plastic and Wound Repair, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China; Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, PR China.
Tianjing YuThe First Affiliated Hospital, Center of Burn & Plastic and Wound Repair, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China.
Yan ChenThe First Affiliated Hospital, Center of Burn & Plastic and Wound Repair, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China.
Qinglai YangCenter for Molecular Imaging Probe, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China.
Kaikai WenBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, PR China; School of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: kaikaiwen@binn.cas.cn.
Junlin LiaoThe First Affiliated Hospital, Center of Burn & Plastic and Wound Repair, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: liaojunlin85@163.com.
Linlin LiBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, PR China; School of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: lilinlin@binn.cas.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the low density of chondrocytes and limited ability to repair damaged extracellular matrix (ECM) in cartilage, many patients with congenital or acquired craniofacial trauma require filler graft materials to support facial structure, restore function, improve self-confidence, and regain socialization. Ultrasound has the capacity to stimulate piezoelectric materials, converting mechanical energy into electrical signals that can regulate the metabolism, proliferation, and differentiation of chondrocytes. This unique property has sparked growing interest in using piezoelectric biomaterials in regenerative medicine. In this review, we first explain the principle behind ultrasound-activated piezoelectric materials and how they generate piezopotential. We then review studies demonstrating how this bioelectricity promotes chondrocyte regeneration, stimulates the secretion of key extracellular components and supports cartilage regeneration by activating relevant signaling pathways. Next, we discuss the properties, synthesis, and modification strategies of various piezoelectric biomaterials. We further discuss recent progresses in the development of ultrasound-activated piezoelectric biomaterials specifically designed for cartilage regeneration. Lastly, we discuss future research challenges facing this technology, ultrasound-activated piezoelectric materials for cartilage regeneration engineering. While the technology holds great promise, certain obstacles remain, including issues related to material stability, precise control over ultrasound parameters, and the integration of these systems into clinical settings. The combination of ultrasound-activated piezoelectric technology with other emerging fields, such as Artificial Intelligence (AI) and cartilage organoid chips, may open new frontiers in regenerative medicine. We hope this review encourages further exploration of ultrasound-activated strategies for piezoelectric materials and their future applications in regenerative medicines.

Indexed as

Biocompatible MaterialsCartilageRegenerationUltrasonic WavesAnimalsHumansTissue EngineeringBiocompatible MaterialsBionicsCartilage regenerationMicroenvironmentPiezoelectric biomaterialsUltrasound

Identifiers

PMID40250302
PMCPMC12433804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.