Evidence map›Paper›PMID 40250282›Full record

ArticlePsychiatry research2025

Quantifying the independent impact of social determinants of health and posttraumatic stress disorder on resource utilization and health outcomes in civilians.

Katarina Irwin, Martin Zagari, Heidi C Waters, Jyoti Aggarwal, Hema K Gandhi, Shawn A DeLuz, Junko Saber, Lisa M Kennedy, Jiayuan Wang, Napoleon B Higgins

Abstract read
In one paragraph

Article in Psychiatry research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katarina IrwinInnopiphany, LLC, USA. Electronic address: katarina.irwin@innopiphany.com.
Martin ZagariInnopiphany, LLC, USA. Electronic address: martin.zagari@innopiphany.com.
Heidi C WatersOtsuka Pharmaceutical Development & Commercialization, Inc, USA. Electronic address: Heidi.Waters@otsuka-us.com.
Jyoti AggarwalOtsuka Pharmaceutical Development & Commercialization, Inc, USA. Electronic address: Jyoti.Aggarwal@otsuka-us.com.
Hema K GandhiOtsuka Pharmaceutical Development & Commercialization, Inc, USA. Electronic address: hema.gandhi@otsuka-us.com.
Shawn A DeLuzInnopiphany, LLC, USA. Electronic address: shawn.deluz01@gmail.com.
Junko SaberInnopiphany, LLC, USA. Electronic address: junko.saber@innopiphany.com.
Lisa M KennedyInnopiphany, LLC, USA. Electronic address: lisa.kennedy@innopiphany.com.
Jiayuan WangInnopiphany, LLC, USA; University of California, Irvine, USA. Electronic address: jiayuan.wang@innopiphany.com.
Napoleon B HigginsBay Pointe Behavioral Health Service, USA. Electronic address: napoleonhiggins@napoleonhigginsmd.com.

Funding

Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7M
Precision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5M
Enhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7M
Adaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6M
University of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9M
California Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4M
All of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1M
New York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3M
SouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8M
Southern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5M
Illinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5M
The New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8M
AOU NIH HHS WB999999NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196
6 · The paper itself

Abstract

Social determinants of health (SDoH) and posttraumatic stress disorder (PTSD) are well-documented risk factors for poor health outcomes, yet their independent contributions to healthcare resource utilization (HCRU) and patient-reported quality of life remain unclear. This retrospective study, using the All of US database, compared civilians with and without PTSD (n = 747, matched on age, sex at birth, race, and ethnicity) and examined whether differences in SDoH, beyond the matched demographics, were associated with poorer health outcomes. Multiple linear regressions were conducted for twelve health outcomes related to HCRU and patient-reported well-being to separate the independent contributory effect of PTSD and SDoH. Across both HCRU and patient-reported well-being, PTSD patients had worse outcomes. SDoH factors accounted for 23.2 % of Outpatient Visits and 50.1 % of Emergency Room Visits among civilians, translating to a $8.82 billion health system burden. The SDoH domains of Employment Status, Stress, and Discrimination were significantly associated with increased HCRU. Further, SDoH factors contributed to more than half (52.4-84.5 %) of poor self-rated well-being outcomes compared with PTSD itself. Self-reported outcomes were affected by a variety of SDoH domains, most prominently Employment Status, Education, and Relationships. These results offer insight into the potential significant independent contribution of unfavorable SDoH in worsening health outcomes among civilians with PTSD.

Indexed as

Patient Acceptance of Health CareSocial Determinants of HealthStress Disorders, Post-TraumaticAdultAgedFemaleHumansMaleMiddle AgedQuality of LifeRetrospective StudiesUnited StatesYoung AdultAll of us research programCivilian PTSDHealth outcomesPosttraumatic stress disorderReal-world evidenceResource utilizationSocial determinants of health

Identifiers

PMID40250282
PMCPMC12370176

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.