Evidence map›Paper›PMID 40250258›Full record

ArticleParkinsonism & related disorders2025

Tongue strength in progressive supranuclear palsy.

Heather M Clark, Julie A Stierwalt, Gabriela Meade, Farwa Ali, Yehkyoung Stephens, Hugo Botha, Nirubol Tosakulwong, Stephen Weigand, Keith A Josephs, Jennifer L Whitwell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heather M ClarkMayo Clinic Rochester Department of Neurology, USA. Electronic address: Clark.heather1@mayo.edu.
Julie A StierwaltMayo Clinic Rochester Department of Neurology, USA.
Gabriela MeadeMayo Clinic Rochester Department of Neurology, USA.
Farwa AliMayo Clinic Rochester Department of Neurology, USA.
Yehkyoung StephensMayo Clinic Rochester Department of Neurology, USA.
Hugo BothaMayo Clinic Rochester Department of Neurology, USA.
Nirubol TosakulwongMayo Clinic Rochester Clinical Trials and Biostatistics, USA.
Stephen WeigandMayo Clinic Rochester Clinical Trials and Biostatistics, USA.
Keith A JosephsMayo Clinic Rochester Department of Neurology, USA.
Jennifer L WhitwellMayo Clinic Rochester Radiology Research, USA.

Funding

Longitudinal multi-modality imaging in progressive apraxia of speech (Diversity Supplement)R01DC012519 · NIDCD · MAYO CLINIC ROCHESTER · PI Jennifer Louise Whitwell · 2013 to 2026
$7.2M
Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy SyndromesR01NS089757 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2015 to 2024
$5.6M
NIDCD NIH HHS R01 DC012519NINDS NIH HHS R01 NS089757
6 · The paper itself

Abstract

purposeTongue weakness is common in patients with neurologic disease, including parkinsonism. The aim of this study is to describe tongue strength in progressive supranuclear palsy and its relationship to dysphagia and dysarthria.

methodsParticipants were 119 (58 female) individuals with probable or possible progressive supranuclear palsy. Each participant underwent a motor speech assessment to determine type and severity of dysarthria. Quantification of dysphagia included the Modified Barium Swallow Impairment Profile, the Penetration-Aspiration Scale, and the Functional Oral Intake Scale. Anterior elevation tongue strength was assessed by measuring maximum pressure exerted by the tongue on an air-filled bulb positioned against the hard palate.

resultsMean maximum tongue elevation pressure was 38 kPa. Tongue strength correlated significantly with age, dysarthria severity, and disease severity. Tongue strength was not differentially affected by dysarthria type, but was weakly correlated with pharyngeal dysphagia severity.

conclusionsAverage tongue strength in speakers with progressive supranuclear palsy is lower than reported for neurologically healthy adults and for patients with Parkinson's Disease. Likely reflecting a combination of age-related loss of muscle mass and damage to the basal ganglia and/or pyramidal tracts, reduced tongue strength on its own does not appear to be a primary driver of swallowing difficulties in this population. Further study is warranted to better understand the physiologic mechanisms contributing to reduced tongue strength in PSP, how tongue strength changes as disease progresses, and what other mechanisms contribute to dysphagia in PSP.

Indexed as

Deglutition DisordersDysarthriaMuscle StrengthSupranuclear Palsy, ProgressiveTongueAgedAged, 80 and overFemaleHumansMaleMiddle AgedSeverity of Illness IndexDysarthriaDysphagiaProgressive supranuclear palsyTongue strength

Identifiers

PMID40250258
PMCPMC12129677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.