Evidence map›Paper›PMID 40250131›Full record

ArticleSchizophrenia research2025

Cultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis.

Ryan M Guest, Katrina Aberizk, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Matcheri S Keshavan, Daniel H Mathalon, Diana O Perkins and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ryan M GuestDepartment of Psychology, Emory University, Atlanta, GA, USA. Electronic address: rmguest@emory.edu.
Katrina AberizkDepartment of Psychology, Emory University, Atlanta, GA, USA.
Jean AddingtonDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Carrie E BeardenDepartments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
Kristin S CadenheadDepartment of Psychiatry, University of California San Diego, San Diego, California, USA.
Tyrone D CannonDepartment of Psychiatry, Yale University, New Haven, CT, USA; Department of Psychology, Yale University, New Haven, CT, USA.
Barbara A CornblattDepartment of Psychiatry, Zucker Hillside Hospital, Glen Oaks, New York, USA.
Matcheri S KeshavanDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA.
Daniel H MathalonDepartment of Psychiatry, University of California San Francisco, San Francisco, California, USA; San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
William S StoneDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Elaine F WalkerDepartment of Psychology, Emory University, Atlanta, GA, USA.

Funding

STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2003 to 2014
$18.6M
1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4M
5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5M
Administrative Supplement Harmonization of At Risk Multisite Observational Networks for Youth(HARMONY)U01MH081928 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STONE, WILLIAM SETH · 2008 to 2018
$7.1M
4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
"7/9" Predictors and Mechanisms of Conversion to PsychosisU01MH081984 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2008 to 2018
$4.2M
Functional Brain Abnormalities in the Schizophrenia ProdromeR01MH076989 · NIMH · YALE UNIVERSITY · PI MATHALON, DANIEL H · 2007 to 2014
$2.3M
NIMH NIH HHS P50 MH066286NIMH NIH HHS R01 MH076989NIMH NIH HHS U01 MH081857NIMH NIH HHS U01 MH081902NIMH NIH HHS U01 MH081928NIMH NIH HHS U01 MH081944NIMH NIH HHS U01 MH081984NIMH NIH HHS U01 MH081988NIMH NIH HHS U01 MH082004NIMH NIH HHS U01 MH082022
6 · The paper itself

Abstract

BACKGROUND & HYPOTHESIS: Prior studies suggest that cognitive batteries normed in the U.S. may not be suitable for populations that differ in English proficiency and/or cultural background. Here, we investigated how cultural variables (i.e., length of residence, native English speaker) influence cognitive performance within a U.S. and Canadian sample of people at clinical high risk for psychosis (CHR-P) and healthy control (HC) participants. STUDY

designThe sample consisted of 925 adolescents and adults (664 CHR-P, 261 HC) from the second cohort of the North American Prodromal Longitudinal Study, including 73 (7.9 %) foreign-born participants and 94 (10.2 %) who reported a language other than English as their first language. Multigroup structural equation modeling was used to estimate effects of cultural variables on MATRICS Consensus Cognitive Battery (MCCB) subtests, separately in each diagnostic group. STUDY

resultsA structural model that generated unique estimates for all parameters in group models was selected. For CHR-P, longer length of residence in U.S./Canada related to better performance on Animal Naming (β = 0.09, p = .01), whereas being a native English speaker related to better performance on Letter-Number Span (β = 0.14, p = .001) and Hopkins Verbal Learning Test - Revised (β = 0.10, p = .03). In contrast, no such relationships were observed among HCs.

conclusionsFindings extend our understanding of how cultural variables may influence presentation of psychosis-risk syndromes and suggest that being a non-native English speaker or having recently immigrated may hinder performance on certain verbal neuropsychological measures.

Indexed as

Cognitive DysfunctionCross-Cultural ComparisonNeuropsychological TestsPsychotic DisordersAdolescentAdultCanadaFemaleHumansLongitudinal StudiesMaleProdromal SymptomsRiskUnited StatesYoung AdultCross-cultural neuropsychologySchizophreniaSemantic fluencyVerbal learningVerbal working memory

Identifiers

PMID40250131
PMCPMC12169887

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.