Evidence map›Paper›PMID 40250105›Full record

ArticleVeterinary microbiology2025

Capsular immunity is necessary for protection against some but not all strains of Glaesserella parasuis.

Samantha J Hau, Shi-Lu Luan, Lucy A Weinert, Paul R Langford, Andrew Rycroft, Brendan W Wren, Duncan J Maskell, Alexander W Dan Tucker, Susan L Brockmeier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samantha J HauNational Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States.
Shi-Lu LuanDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Lucy A WeinertDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Paul R LangfordSection of Paediatrics, Department of Medicine, Imperial College London, St. Mary's Campus, London, UK.
Andrew RycroftThe Royal Veterinary College, Hawkshead Campus, Hatfield, United Kingdom.
Brendan W WrenFaculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Duncan J MaskellDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Alexander W Dan TuckerDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Susan L BrockmeierNational Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States. Electronic address: Susan.Brockmeier@usda.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaesserella parasuis is the causative agent of Glässer's disease in pigs and results in significant losses to the swine industry annually. Due to the serovar and strain specific response associated with many bacterin vaccines, there has been difficulty generating broad heterologous protection. Here, an unencapsulated G. parasuis mutant (HS069∆cap) was assessed as a bacterin vaccine and compared to a bacterin made from the encapsulated parent strain, against challenge with the homologous, parent strain (serovar 5) as well as four heterologous challenge strains (serovar 1, 4, 5, and 14). Both the HS069 and HS069∆cap bacterins generated high titers to the homologous and heterologous strains. The HS069∆cap bacterin was able to provide protection against the parent strain as well as 12939 (serovar 1), 2170B (serovar 4), and MN-H (serovar 13), but was unable to protect animals from challenge with Nagasaki (serovar 5). In contrast, the HS069 bacterin was able to provide protection against all challenge strains, showing the importance of serovar specific immunity against the challenge strain Nagasaki. This appears to be due to the production of a more abundant and well-organized capsule in Nagasaki as compared to HS069. This study indicates HS069∆cap is a good candidate strain for bacterin development; however, it may be less able to provide protection against highly encapsulated strains of G. parasuis.

Indexed as

Bacterial CapsulesBacterial VaccinesHaemophilus InfectionsHaemophilus parasuisSwine DiseasesAnimalsAntibodies, BacterialHaemophilus VaccinesSerogroupSwineAntibodies, BacterialBacterial VaccinesHaemophilus VaccinesBacterinGlaeserella parasuisGlasser’s diseaseSwineVaccine

Identifiers

PMID40250105
PMCPMC12094177

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.