Evidence map›Paper›PMID 40249815›Full record

ArticleScience advances2025

A genetic variant in

Nathaniel P Mohar, Christopher J Langland, Zachary Darr, Jill Viles, Steven A Moore, Benjamin W Darbro, Lori L Wallrath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathaniel P MoharInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-1990-4600
Christopher J LanglandDepartment of Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0009-0009-6511-1645
Zachary DarrDepartment of Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0009-0002-4300-7694
Jill VilesIndependent researcher, Gowrie, Iowa, USA.
Steven A MooreDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Benjamin W DarbroInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-9279-356X
Lori L WallrathInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-4391-7199

Funding

Muscular Dystrophy Specialized Research Center: Project 2P50NS053672 · NINDS · UNIVERSITY OF IOWA · PI KEVIN P. CAMPBELL · 2020 to 2026
$11.9M
NINDS NIH HHS P50 NS053672
6 · The paper itself

Abstract

Mutations in

Indexed as

Lamin Type AMuscular DystrophiesSignal TransductionSmad7 ProteinAdultAnimalsDisease Models, AnimalFemaleHumansMaleMuscle, SkeletalMutationLamin Type ALMNA protein, humanSmad7 ProteinSMAD7 protein, human

Identifiers

PMID40249815
PMCPMC12007578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.