Evidence map›Paper›PMID 40249812›Full record

ArticleScience advances2025

Progesterone signaling in oviductal epithelial cells modulates the immune response to support preimplantation embryonic development.

Emily A McGlade, Jiude Mao, Kalli K Stephens, Ryan M Marquardt, Feyza Nur Arguc, Peter F Lais, San-Pin Wu, Sarayut Winuthayanon, Haval Shirwan, Esma S Yolcu and 5 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Developmental origins of immunometabolic health.Immunometabolism (Cobham, Surrey) · 2026
    Review
  5. Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Emily A McGladeDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0003-4979-9979
Jiude MaoDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0003-0594-0571
Kalli K StephensDivision of Animal Sciences, College of Agriculture, Food and Natural Resources, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0002-9323-3764
Ryan M MarquardtReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 USA.ORCID 0000-0002-6597-4506
Feyza Nur ArgucDivision of Pediatric Research, School of Medicine, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0003-1004-2653
Peter F LaisReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 USA.ORCID 0009-0007-4942-8744
San-Pin WuReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 USA.ORCID 0000-0001-9626-784X
Sarayut WinuthayanonDivision of Animal Sciences, College of Agriculture, Food and Natural Resources, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0002-8439-0389
Haval ShirwanDivision of Pediatric Research, School of Medicine, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0002-1657-9470
Esma S YolcuDivision of Pediatric Research, School of Medicine, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0002-4312-8798
Mark I HunterDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0002-8616-5003
James K PruProgram in Reproductive Biology, Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA.ORCID 0000-0003-2251-4494
John P LydonDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Francesco J DeMayoReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 USA.ORCID 0000-0002-9480-7336
Wipawee WinuthayanonDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0002-5196-8471

Funding

The actions of steroid hormones on oviduct functionR01HD097087 · NICHD · WASHINGTON STATE UNIVERSITY · PI WINUTHAYANON, WIPAWEE · 2019 to 2023
$1.7M
The Role of Progesterone Receptor in the Oviduct Epithelium for Pregnancy EstablishmentF31HD107807 · NICHD · WASHINGTON STATE UNIVERSITY · PI MCGLADE, EMILY A · 2021 to 2021
$28k
The Role of SRF in Uterine HomeostasisFI2GM154603 · NIGMS · U.S. NATIONAL INST OF ENVIRON HLTH SCIS · PI MARQUARDT, RYAN · 2024 to 2024
–
NICHD NIH HHS F31 HD107807NICHD NIH HHS R01 HD097087NIGMS NIH HHS FI2 GM154603
6 · The paper itself

Abstract

More than 60% of pregnancy losses occur during the first trimester, highlighting the need to understand the role of the oviduct in early pregnancy. In this study, we conditionally ablated the classical progesterone receptor (

Indexed as

Embryonic DevelopmentEpithelial CellsFallopian TubesOviductsProgesteroneSignal TransductionAnimalsBlastocystFemaleInterleukin-22InterleukinsMicePregnancyReceptors, ProgesteroneInterleukin-22InterleukinsProgesteroneReceptors, Progesterone

Identifiers

PMID40249812
PMCPMC12007591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.