Evidence map›Paper›PMID 40249803›Full record

ArticleScience advances2025

Sustained mTORC1 activation in activated T cells impairs vaccine responses in older individuals.

Xiaorong Lin, Yanhua Du, Shuo Kan, Junjie Chen, Yunxue Yin, Linlin Li, Jingwen Chen, Wenrong Jiang, Wenqiang Cao, Chulwoo Kim and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaorong LinMultiscale Research Institute for Complex Systems, Fudan University, Shanghai, China.ORCID 0009-0003-4131-1470
Yanhua DuDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID 0009-0003-3043-4854
Shuo KanMultiscale Research Institute for Complex Systems, Fudan University, Shanghai, China.ORCID 0000-0001-6325-8285
Junjie ChenSchool of Medicine, Shanghai University, Shanghai, China.ORCID 0009-0008-8468-4943
Yunxue YinMultiscale Research Institute for Complex Systems, Fudan University, Shanghai, China.
Linlin LiMultiscale Research Institute for Complex Systems, Fudan University, Shanghai, China.
Jingwen ChenMultiscale Research Institute for Complex Systems, Fudan University, Shanghai, China.
Wenrong JiangDepartment of Laboratory Medicine, Huadong Hospital, Fudan University, Shanghai, China.ORCID 0009-0000-4678-3598
Wenqiang CaoKey Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang, China.ORCID 0000-0002-5024-0817
Chulwoo KimDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-5736-8170
Liang ChenSchool of Medicine, Shanghai University, Shanghai, China.ORCID 0000-0002-0440-0306
Shiwen WangDepartment of Laboratory Medicine, Huadong Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-6294-4865
Jorg J GoronzyDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Jun JinMultiscale Research Institute for Complex Systems, Fudan University, Shanghai, China.ORCID 0000-0002-5018-144X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cell aging contributes to the lower vaccine efficacy in older adults, yet the molecular mechanism remains elusive. Here, we show the density of initially responding naïve CD4

Indexed as

AgingLymphocyte ActivationMechanistic Target of Rapamycin Complex 1VaccinesAgedAnimalsCell DifferentiationFemaleHumansMiceSignal TransductionMechanistic Target of Rapamycin Complex 1Vaccines

Identifiers

PMID40249803
PMCPMC12007566

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.