Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Kanishka SenarathDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.ORCID 0000-0003-3326-9738
Isaac J FisherJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907.ORCID 0000-0001-5774-1000
Wonjo JangDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.ORCID 0000-0002-1928-8978
Sumin LuDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Asuka InoueMolecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0003-0805-4049
Evi KostenisMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn 53115, Germany.ORCID 0000-0001-8284-5514
Angeline M LyonJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907.
Nevin A LambertDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.ORCID 0000-0001-7550-0921
Funding
Conventional and unconventional GPCR-G protein couplingR35GM145284 · NIGMS · AUGUSTA UNIVERSITY · PI Nevin Alan Lambert · 2022 to 2026
$1.8M
Mechanisms Underlying Regulation of PLCbeta by heterotrimeric G proteinsR01GM152701 · NIGMS · PURDUE UNIVERSITY · PI Angeline Marie Lyon · 2024 to 2026
$1.1M
Deutsche Forschungsgemeinschaft (DFG) 214362475/GRK1873/3HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM152701HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM145284Japan Agency for Medical Research and Development (AMED) JP22ama121038Japan Agency for Medical Research and Development (AMED) JP22zf0127007MEXT | Japan Science and Technology Agency (JST) JPMJFR215TMEXT | Japan Science and Technology Agency (JST) JPMJMS2023MEXT | Japan Society for the Promotion of Science (JSPS) JP21H04791MEXT | Japan Society for the Promotion of Science (JSPS) JP24K21281NIGMS NIH HHS R01 GM152701NIGMS NIH HHS R35 GM145284
6 · The paper itself
Abstract
Phospholipase Cβ (PLCβ) enzymes are the principal effectors activated by G
Indexed as
GTP-Binding Protein alpha Subunits, Gq-G11Phospholipase C betaAnimalsCell MembraneHEK293 CellsHumansPhosphatidylinositol 4,5-DiphosphateProtein DomainsGTP-Binding Protein alpha Subunits, Gq-G11Phosphatidylinositol 4,5-DiphosphatePhospholipase C betaGPCRGαqphospholipasePIP2PLCβ
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
An integrated mechanism of G · full record | OpenQuestion