Evidence map›Paper›PMID 40249702›Full record

ArticleCell reports2025

Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response.

Chia-Yang Chen, Zhengyao Shao, Guihua Wang, Bo Zhao, Haley A Hardtke, Josh Leong, Tiffany Zhou, Y Jessie Zhang, Hong Qiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. How chromatin senses plant hormones.Current opinion in plant biology · 2024
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Chia-Yang ChenInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Zhengyao ShaoInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Guihua WangInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Bo ZhaoInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Haley A HardtkeDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Josh LeongDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Tiffany ZhouDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Y Jessie ZhangDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Hong QiaoInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: hqiao@austin.utexas.edu.

Funding

Molecular mechanisms of interplay between ethylene signaling and chromatin regulation in ArabidopsisR01GM115879 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI QIAO, HONG · 2015 to 2023
$2.9M
Deciphering the phosphorylation pattern of RNA polymerase II for eukaryotic transcriptionR35GM148356 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yan Jessie Zhang · 2023 to 2026
$2.3M
NIGMS NIH HHS R01 GM115879NIGMS NIH HHS R35 GM148356
6 · The paper itself

Abstract

Ethylene plays essential roles in plant development, growth, and defense responses by controlling transcriptional reprogramming, in which ETHYLENE INSENSITIVE 2-C-terminal end (EIN2-C)-directed regulation of histone acetylation is the first key step for chromatin to perceive ethylene signaling. However, the histone acetyltransferase (HAT) in this process remains unknown. Here, we identify HAF2 as the missing HAT, as HAF2 mutations confer ethylene hyposensitivity. HAF2 interacts with EIN2-C in response to ethylene, and its bromodomain preferentially binds H3K14ac, while its HAT domain acetylates H3K14 and H3K23, favoring H3K14. Chromatin immunoprecipitation sequencing confirms HAF2's role in regulating H3K14ac and H3K23ac. Additionally, HAF2 cooperates with the pyruvate dehydrogenase complex (PDC) to modulate histone acetylation in an EIN2-dependent manner. Our findings establish HAF2 as the key HAT that, together with EIN2-C and PDC, orchestrates H3K14ac and H3K23ac deposition, preferentially targeting H3K14, in response to ethylene.

Indexed as

ArabidopsisArabidopsis ProteinsEthylenesHistone AcetyltransferasesHistonesPyruvate Dehydrogenase ComplexAcetylationGene Expression Regulation, PlantProtein BindingArabidopsis ProteinsethyleneEthylenesHistone AcetyltransferasesHistonesPyruvate Dehydrogenase ComplexCP: PlantsethylenehistonePDCtranscriptional regulation

Identifiers

PMID40249702
PMCPMC12129654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.