Evidence map›Paper›PMID 40249667›Full record

ReviewEpigenomics2025

Mom genes and dad genes: genomic imprinting in the regulation of social behaviors.

Erin M O'Leary, Paul J Bonthuis

Abstract readReview
In one paragraph

Review in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erin M O'LearyNeuroscience Program, University of Illinois, Urbana, IL, USA.ORCID 0000-0003-2220-2757
Paul J BonthuisNeuroscience Program, University of Illinois, Urbana, IL, USA.ORCID 0000-0001-7601-9486

Funding

Genomic imprinting in circuits for social behaviorR00MH111912 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BONTHUIS, PAUL JEFFREY · 2020 to 2022
$747k
NIMH NIH HHS R00 MH111912
6 · The paper itself

Abstract

Genomic imprinting is an epigenetic phenomenon in mammals that affects brain development and behavior. Imprinting involves the regulation of allelic expression for some genes in offspring that depends on whether alleles are inherited from mothers compared to fathers, and is thought to provide parental control over offspring social behavior phenotypes. Imprinted gene expression is prevalent in the mammalian brain, and human imprinted gene mutations are associated with neurodevelopmental disorders and neurodivergent social behavior in Prader-Willi Syndrome, Angelman Syndrome, and autism. Here, we provide a review of the evidence that imprinted genes influence social behaviors across major neurodevelopmental stages in humans and mouse animal models that include parent-infant interactions, juvenile sociability, and adult aggression, dominance, and sexual behavior.

Indexed as

Genomic ImprintingSocial BehaviorAnimalsFemaleHumansMaleMicePrader-Willi SyndromeaggressionautismGenomic imprintingneurodevelopmentparental behaviorsociabilitysocial behaviorsocial stability

Identifiers

PMID40249667
PMCPMC12140492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.