Evidence map›Paper›PMID 40249558›Full record

ArticleJournal of separation science2025

Electrokinetic Chromatography-based Micro Methods for Separation and Physiochemical Characterization of Very Hydrophobic Pharmaceuticals.

Robert Minkner, Hermann Wätzig

Abstract read
In one paragraph

Article in Journal of separation science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert MinknerInstitute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany.ORCID https://orcid.org/0000-0003-3651-2596
Hermann WätzigInstitute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany.ORCID https://orcid.org/0000-0002-7456-0612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study established an efficient separation of the highly hydrophobic analytes fenofibrate, orlistat, lumefantrine and a micelle marker using microemulsion electrokinetic capillary chromatography. A starting buffer with sodium dodecyl sulphate, heptane and butan-1-ol resulted in a partial separation of the analytes. Various experimental parameters were investigated, including voltage, sample loading time, buffer composition and temperature. An excellent separation was achieved, and compounds with hydrophobicity of up to a calculated log P of 10.2 (est. 12) could be clearly distinguished. Due to observed variabilities in retention time when changing the capillaries, it is advisable to calibrate with a standard mixture before each measurement series.

Indexed as

Chromatography, Micellar Electrokinetic CapillaryFenofibrateHydrophobic and Hydrophilic InteractionsLactonesOrlistatPharmaceutical PreparationsFenofibrateLactonesOrlistatPharmaceutical Preparationselectrokinetic chromatographyhydrophobicityMEEKCpharmaceuticals

Identifiers

PMID40249558
PMCPMC12007571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.