Evidence map›Paper›PMID 40249534›Full record

Observational studyJapanese journal of ophthalmology2025

Identification of risk factors for persistent corneal edema associated with acute corneal hydrops in keratoconus.

Takaaki Aichi, Koji Kitazawa, Renako Kozaki, Yohei Yamashita, Motohiro Itoi, Kengo Yoshii, Keiko Yamagishi, Hisayo Higashihara, Mari Osawa, Yoko Hyakutake and 2 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Takaaki AichiDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Koji KitazawaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan. kkitazaw@koto.kpu-m.ac.jp.ORCID http://orcid.org/0000-0003-2203-5776
Renako KozakiDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Yohei YamashitaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Motohiro ItoiDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Kengo YoshiiDepartment of Mathematics and Statistics in Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Keiko YamagishiDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Hisayo HigashiharaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Mari OsawaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Yoko HyakutakeDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Hideki KoizumiDepartment of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Chie SotozonoDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to investigate the clinical characteristics of acute corneal hydrops (ACH) in patients with keratoconus and to examine the risk factors for persistent corneal edema. STUDY

designRetrospective observational study.

methodsThe study included 98 patients (106 eyes) diagnosed with ACH between February 2009 and August 2023 at Kyoto Prefectural University of Medicine. Seventy-seven eyes with clear data on both onset and resolution were analyzed for the risk factors for persistent corneal edema. Clinical characteristics, duration of corneal edema, and associated risk factors such as seasonal variations, edema area, allergic diseases, eye rubbing, and neurodevelopmental disorders (including Down syndrome) were collected and analyzed.

resultsThe study included 90 male (91.8%) and 8 female (8.2%) patients. The mean (SD) age at ACH onset was 33.3 (13.8) years (range, 14-80). ACH occurred most prevalently during the spring season (n = 39, 36.8%). Allergic diseases were present in 59 eyes (55.7%); eye rubbing, in 58 eyes (54.7%); and neurodevelopmental disorders, in 9 eyes (8.5%). Corneal edema resolved within 3 months in 55 eyes (71.4%), whereas it persisted for over 3 months in 22 eyes (28.6%). Multivariate analysis showed that a large edema area, ≥50%, was a significant risk factor for persistent corneal edema of more than 3 months in ACH patients (odds ratio, 7.41; 95% CI, 1.95-33.02; P = .005).

conclusionLarge corneal edema at ACH onset carries a high risk of persistent corneal edema. These patients should be managed more carefully to resolve the corneal edema earlier.

Indexed as

CorneaCorneal EdemaKeratoconusVisual AcuityAcute DiseaseAdolescentAdultAgedAged, 80 and overCorneal TopographyFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesAcute corneal hydropsAllergic diseasesDown syndromeKeratoconusRisk factors

Identifiers

PMID40249534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.