Evidence map›Paper›PMID 40249513›Full record

ArticleJournal of neuro-oncology2025

International multicenter study of stereotactic radiosurgery for bladder cancer brain metastases.

Rémi Perron, Christian Iorio-Morin, Tomas Chytka, Gabriela Simonova, Veronica Chiang, Charu Singh, Ajay Niranjan, Zhishuo Wei, L Dade Lunsford, Selcuk Peker and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rémi PerronDivision of Neurosurgery, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, Qc, Canada.
Christian Iorio-MorinDivision of Neurosurgery, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, Qc, Canada.
Tomas ChytkaDepartment of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic.
Gabriela SimonovaDepartment of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic.
Veronica ChiangDepartment of Neurosurgery, Yale University, New Haven, CT, USA.
Charu SinghDepartment of Radiation Oncology, Yale University, New Haven, CT, USA.
Ajay NiranjanDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Zhishuo WeiDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
L Dade LunsfordDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Selcuk PekerDepartment of Neurosurgery, Koc University School of Medicine, Istanbul, Turkey.
Yavuz SamanciDepartment of Neurosurgery, Koc University School of Medicine, Istanbul, Turkey.
Jennifer PetersonDepartment of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.
Richard RossDepartment of Radiation Oncology, University of Colorado, Denver, CO, USA.
Chad G RusthovenDepartment of Radiation Oncology, University of Colorado, Denver, CO, USA.
Cheng-Chia LeeDepartment of Neurosurgery, Taipei Veteran General Hospital, Taipei, Taiwan.
Huai-Che YangDepartment of Neurosurgery, Taipei Veteran General Hospital, Taipei, Taiwan.
Ulas YenerDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, USA.
Jason SheehanDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, USA.
Douglas KondziolkaDepartment of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.
David MathieuDivision of Neurosurgery, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, Qc, Canada. david.mathieu@usherbrooke.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBladder cancer rarely metastasizes to the brain. This study was performed to evaluate stereotactic radiosurgery (SRS) for the management of bladder cancer brain metastases.

methodsCases of bladder cancer brain metastases treated with SRS were collected by members of the International Radiosurgery Research Foundation (IRRF) and outcome data was analyzed for patients with at least one clinical or imaging follow-up.

results103 patients received SRS for 301 brain metastases. Median age at SRS was 68 and 73.8% of patients were male. Median KPS was 80%. Median time from primary to brain metastases diagnosis was 18 months. At the time of SRS, 50% of patients had other systemic metastases. The median number of metastases treated was 1, and median cumulative SRS volume was 1.16 cc. Most patients had single fraction SRS using a median margin dose of 18 Gy. At the time of analysis, 9.7% of patients were alive. Median survival after SRS was 7 months. Local control was achieved for 89.3% of metastases, 42% of patients developed new remote brain metastases, and 4.9% had leptomeningeal dissemination. Subsequent management included repeat SRS in 21.7%, surgical resection in 8.8% and WBRT in 7.6% of patients. At last follow-up, 32.1% of patients had improvement of their symptoms, whereas 38.5% remained stable. Adverse radiation effects occurred in 4.3% of treated metastases. On multivariate analyses, KPS ≥ 80% and non-urothelial histology predicted improved survival, while absence of corticosteroid intake predicted longer tumor control.

conclusionBladder cancer brain metastases can be safely managed with SRS.

Indexed as

Brain NeoplasmsRadiosurgeryUrinary Bladder NeoplasmsAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeBladder cancerBrain metastasesGamma knifeStereotactic radiosurgery

Identifiers

PMID40249513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.