Evidence map›Paper›PMID 40249510›Full record

ArticleLung2025

Exploration of IgE Specific to Staphylococcal Serine Protease-Like Protein A as a Phenotypic Marker in Late-Onset Asthma.

Ha-Kyeong Won, Jiwon Lee, Kyung Eun Park, Jun-Pyo Choi, Woo-Jung Song

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ha-Kyeong WonDivision of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.ORCID http://orcid.org/0000-0001-8127-7885
Jiwon LeeInstitute of Allergy and Clinical Immunology, Asan Medical Research Center, Seoul, Korea.ORCID http://orcid.org/0009-0009-1584-2415
Kyung Eun ParkUniversity of Ulsan College of Medicine, Seoul, Korea.ORCID http://orcid.org/0009-0006-3459-8508
Jun-Pyo ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID http://orcid.org/0000-0001-8925-1786
Woo-Jung SongDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. swj0126@amc.seoul.kr.ORCID http://orcid.org/0000-0002-4630-9922

Funding

a National Research Foundation of Korea (NRF) grant funded by the Korean Government NRF-2022R1C1C1011057a Veterans Health Service Medical Center Research Grant, Republic of Korea VHSMC 24033
6 · The paper itself

Abstract

purposeStaphylococcus aureus (SA) secretes pro-allergic molecules, including staphylococcal enterotoxins (SEs) and serine protease-like proteins (Spls). While IgE sensitization to SE has been relatively well documented in relation to severe eosinophilic late-onset asthma, the clinical implications of IgE sensitization to Spls remain unclear. We explored the clinical relevance of Spl-IgE in late-onset asthmatics.

methodsAdults with late-onset asthma (onset age ≥ 40 years) were prospectively enrolled. Demographic and clinical characteristics were assessed, and serum levels of total IgE, SE-IgE, and SplA-IgE were measured. Nasal swabs were obtained to assess SA colonization.

resultsAmong 109 participants, SplA-IgE levels were significantly associated with blood eosinophilia, total IgE, SE-IgE sensitization, and male sex, but not with SA colonization, asthma severity, or lung function.

conclusionSensitization to SplA-IgE may indicate a type 2 inflammatory phenotype, but its role in asthma warrants further investigation.

Indexed as

AsthmaImmunoglobulin EStaphylococcus aureusAdultAgedAge of OnsetBiomarkersEnterotoxinsFemaleHumansMaleMiddle AgedPhenotypeProspective StudiesBiomarkersEnterotoxinsImmunoglobulin EAsthmaEnterotoxinsImmunoglobulin ESerine protease-like proteinsStaphylococcus aureus

Identifiers

PMID40249510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.