Observational studyEndocrine2025
Bone evaluation and relationship between body composition and bone mass in anorexia nervosa followed up by a multidisciplinary team.
Observational study in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeAnorexia nervosa is a psychiatric disorder characterized by self-imposed fasting and significant weight loss, leading to nutrient deficiencies that disrupt bone metabolism. This cross-sectional observational study aimed to characterize the bone health of women with anorexia nervosa using dual-energy X-ray absorptiometry (DXA), trabecular bone score (TBS), and 3D shaper analysis.
methodsThe study involved 12 women diagnosed with anorexia nervosa monitored by a multidisciplinary team and 11 control subjects. Both groups underwent blood sampling and assessments with DXA, TBS, and 3D shaper analysis.
resultsThe results indicated that areal bone mineral density (aBMD) and Z-scores at the total hip and femoral neck were significantly lower in the anorexia group compared to controls (p < 0.05). Additionally, the fat mass index was reduced in women with anorexia (p < 0.05). Appendicular lean mass index (ALMI) was similar between the two groups. 3D shaper analysis revealed that surface BMD (sBMD), volumetric BMD (vBMD), integral vBMD, and trabecular vBMD were generally lower in the anorexia group. Associations were found between proximal femur 3D parameters and total hip and femoral neck aBMD. Moreover, significant correlations were observed between total cortical vBMD, total cortical sBMD, integral vBMD, and TBS. ALMI was associated with total cortical thickness and showed a trend toward association with femoral neck Z-score.
conclusionIn addition to previous studies indicating bone impairment in AN using DXA and TBS, the present study suggests that the 3D Shaper is also capable of detecting bone loss in this disorder. Therefore, the data encourage the further studies to assess the role of the 3D Shaper in prediction of fracture.
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Registered trials
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