ArticleMethods in molecular biology (Clifton, N.J.)2025
Protein-Protein Interactions of Odorant and G Protein-Coupled Receptors: A BRET Analysis Approach.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Odorant receptors (ORs), the largest subfamily of G protein-coupled receptors, are pivotal not only for olfactory detection in the nose but also for various biological functions in extra-nasal tissues. The functional characterization of ORs presents significant challenges, especially due to the difficulty of achieving their surface expression in in vitro systems. Research indicates that interactions between ORs and other receptors, as well as OR multimerization, are crucial for their membrane localization and the modulation of signaling pathways. Utilizing the bioluminescence resonance energy transfer (BRET) assay, a technique for investigating protein-protein interactions, our study quantifies the interactions between ORs and various receptors. This approach provides novel insights into OR molecular dynamics, emphasizing the role of OR multimerization. By exploring into these complexities, our work aims to enhance the understanding of cellular signaling mechanisms and promote the development of innovative therapeutic strategies.
Indexed as
Identifiers
40249490What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.