ArticleJournal of breast imaging2025
Quantitative Changes in Breast Density and Mammographic Features Induced by Pregnancy and Lactation: A Longitudinal Study.
Article in Journal of breast imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Volumetric Quantification of Breast Tissue Composition Using Transmission Ultrasound: A Validation Study Against MRI.Ultrasound in medicine & biology · 2026Observational
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Authors and funding
12 authors.
Funding
Abstract
objectiveQuantitative changes in mammographic properties during pregnancy and lactation remain underexplored. Therefore, the purpose of this study was to quantify mammographic changes in the breast from prepregnancy through lactation to postweaning at the individual level.
methodsMammograms of 39 women at elevated risk (mean age 38.7 years) who underwent 3 sequential examinations spanning the lactation period were retrospectively analyzed. Volpara-derived mammographic properties, including breast volume, fibroglandular tissue volume, volumetric breast density, compression force, and radiation dose, were automatically extracted and were statistically compared between the periods.
resultsSignificant longitudinal changes in breast tissue were observed. During lactation, breast volume increased by 45%, fibroglandular tissue volume increased by 138.5%, and volumetric breast density increased by 53.2% compared with prepregnancy levels (P <.001 for all). After weaning, these values decreased by 23.3%, 52.8%, and 27.3%, respectively, compared with lactation (P <.001 for all). Breast compression was decreased by 22.3% on average during lactation compared with prepregnancy (P <.001), while it was not different between lactation and postweaning (P = .11). The radiation dose during lactation increased by 20% compared with both prepregnancy (P = .004) and postweaning (P = .005).
conclusionThe temporal changes in mammographic properties from prepregnancy to lactation include significant increases in breast volume, fibroglandular tissue volume, breast density, and radiation dose, along with a decrease in compression force. While these changes reverse from lactation to postweaning, they generally do not return to prepregnancy levels.
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