ArticleThe ISME journal2025
Muribaculum intestinale restricts Salmonella Typhimurium colonization by converting succinate to propionate.
Article in The ISME journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Dietary conjugated linoleic acid enhances resistance toGut microbes · 2026Article
- Muribaculum as a microbial contributor of rifaximin-induced mucosal protection during chemotherapy.Gut microbes · 2026Article
- Perinatal ampicillin exposure alters murine maternal fecal bile acid and acylcarnitine profiles.Gut microbes · 2026Article
- Circadian synchronization between diet and gut microbiota in modulating host's health.Gut microbes · 2026Review
- Targeted activation of PPARG or AKT1 alleviates liver injury in mice with type 2 diabetes and sepsis by modulating inflammatory and metabolic pathways.Annals of medicine · 2026Article
- Dietary Fiber-Associated Differences in Gut Microbial Community Composition and Predicted Short-Chain Fatty Acid-Related Functional Potential: An In Silico Re-Analysis of 16S rRNA Data.International journal of molecular sciences · 2026Article
- Bifidobacterium animalis subsp. lactis and Enterococcus hirae Enhance Immunity by Modulating Gut Microbiota and Metabolic Pathways in Immunosuppressed Mice.Probiotics and antimicrobial proteins · 2026Article
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Gut-protective metabolic phenotype for diarrhoeal remission caused by an environmental probiotic thermophile.Microbiome · 2026Article
- Laminaria extract reshapes the gut microbiota and TCA cycle-centered metabolic profiles associated with immune modulation in Hu lambs.BMC veterinary research · 2026Article
- Cichorium intybus L. polysaccharide improves growth performance and colonic barrier function in weaned piglets via the microbiota-HDCA-TGR5-Akt-NF-κB signaling axis: validation by FMT and in vitro models.Journal of animal science and biotechnology · 2026Article
- Integrated multi-omics reveals Enterococcus faecalis JM263 alleviates high-concentrate diet-induced hepatic injury via the gut-liver axis in goats.Microbiome · 2026Article
- Effects of FermentedAnimals : an open access journal from MDPI · 2026Article
- Dietary regulation on gut resistome linked with microbial amino acid metabolism in pigs.Animal microbiome · 2026Article
- Comprehensive Sampling Across Seasons and Habitats Revealed the Composition and Functional Attributes of Gut Microbiota Enterotypes in Subterranean Rodents.Ecology and evolution · 2026Article
- From association to intervention: Muribaculaceae driven SCFAs production enhances boar semen quality via inflammation alleviation.NPJ biofilms and microbiomes · 2026Article
- Role and Mechanisms of Gut Microbiota in Infectious Diseases: Recent Evidence from Animal Models.Biology · 2026Review
- Review
- Ursodeoxycholic acid alleviates high-fat diet-induced liver injury by modulating gut microbiota-mediated bile acid metabolism: an integrated microbiota-metabolomics analysis.Frontiers in nutrition · 2026Article
- Divergent pathways of mango fractions in promoting metabolic health: from gut microbiota remodeling to direct systemic regulation.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Insufficient dietary fiber intake is associated with dysbiosis and compromised colonization resistance (CR) to enteric infections. However, a detailed understanding of the relationship between dietary fiber insufficiency and CR remains elusive. Our study aimed to delineate the impact of fiber deprivation on gut microbiome and CR in a murine model with Salmonella Typhimurium infection. Our findings indicate that dietary fiber deprivation resulted in impaired CR and depletion of commensal bacteria Muribaculaceae. By combining dietary switch, FMT, and genomic analysis, we identify Muribaculum intestinale as a candidate bacterium, capable of converting succinate into propionate. Oral administration of Muribaculum intestinale augmented CR to Salmonella Typhimurium, accompanied by succinate reduction and propionate elevation. Dietary supplementation of propionate, but not succinate, enhanced CR to Salmonella Typhimurium in mice consuming a fiber-free diet. Taken together, our research identified a crucial metabolic pathway encoded by gut microbiome underlying CR, providing an intervention strategy for combatting enteric infections among Western diet-consuming populations.
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