ArticleCNS neuroscience & therapeutics2025
High-Density Electroencephalography Detects Spatiotemporal Abnormalities in Brain Networks in Patients With Glioma-Related Epilepsy.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
aimsThe current study aimed to investigate brain network abnormalities in glioma-related epilepsy (gre) patients through high-density electroencephalography (eeg) data analysis.
methodsThe study included 35 patients with newly diagnosed frontal gliomas. All participants underwent 128-channel resting-state EEG recordings before surgery. Afterward, graph theory and microstate analyses were performed, and the resulting metrics were compared between patients with GRE and those without GRE.
resultsThe network topology analysis demonstrated that the GRE group had a higher clustering coefficient, global efficiency, and local efficiency; a lower characteristic path length; and a higher small-worldness coefficient than the non-GRE group (adjusted p < 0.05 for all). Additionally, the microstate analysis indicated that the GRE group had lower occurrence and global explained variance of microstate E and higher global explained variance of microstate D (adjusted p < 0.05 for all). Moreover, the occurrence of microstate D was significantly negatively correlated with the maximum tumor diameter in the non-GRE group (r = -0.542, p = 0.009).
conclusionThe current study revealed specific brain network abnormalities in GRE patients based on graph theory and microstate analyses of resting-state high-density EEG data. These findings can enhance our comprehension of the mechanisms behind GRE and offer potential biomarkers for improving individualized management of glioma patients.
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