Evidence map›Paper›PMID 40249101›Full record

ArticleCardiovascular research2025

Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease.

Anne France Cayron, Sandrine Morel, Maral Azam, Julien Haemmerli, Tomohiro Aoki, Philippe Bijlenga, Eric Allémann, Brenda Renata Kwak

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05526352 (@neurIST), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05526352 recruitingnot on this map

@neurIST : Informatique biomédicale intégrée Pour la Gestion Des anévrismes cérébraux

Typeobservational_patient_registrySponsorUniversity Hospital, GenevaRan2015 to 2040Enrolled20,000ConditionsIntracranial Aneurysm
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anne France CayronDepartment of Pathology and Immunology, University of Geneva, Rue Michel-Servet 1, Geneva CH-1211, Switzerland.ORCID 0000-0002-9408-7295
Sandrine MorelDepartment of Pathology and Immunology, University of Geneva, Rue Michel-Servet 1, Geneva CH-1211, Switzerland.ORCID 0000-0003-1538-3553
Maral AzamDepartment of Pathology and Immunology, University of Geneva, Rue Michel-Servet 1, Geneva CH-1211, Switzerland.
Julien HaemmerliDivision of Neurosurgery, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Tomohiro AokiDepartment of Pharmacology, The Jikei University School of Medicine, Tokyo, Japan.
Philippe BijlengaDivision of Neurosurgery, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.ORCID 0000-0002-3586-2757
Eric AllémannSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-6598-9521
Brenda Renata KwakDepartment of Pathology and Immunology, University of Geneva, Rue Michel-Servet 1, Geneva CH-1211, Switzerland.ORCID 0000-0003-0015-0044

Funding

Fondation Privée des Hôpitaux Universitaires de Genèv RC05-02Gottfried und Julia Bangerter-Rhyner-StiftungSwiss Heart Foundation FF22011Swiss National Science Foundation 320030-231430Wolfermann-Nägeli-Stiftung
6 · The paper itself

Abstract

aimsPolycystic kidney disease (PKD) patients have a high intracranial aneurysms (IAs) incidence and risk of rupture. The mechanisms that make PKD patients more vulnerable to IA disease are still not completely understood. The PCK rat is a well-known PKD model and has been extensively used to study cyst development and kidney damage. Here, we used this rat model to study IA induction and vulnerability. METHODS AND

resultsIAs were induced in wild-type (WT) and PCK rats and their incidence was followed. Variation in the anatomy of the circle of Willis was studied in PCK rats and PKD patients. Immunohistochemistry was performed in rat IAs and in human ruptured and unruptured IAs from patients enrolled in the @neurIST observational cohort. An increased frequency of fatal aortic dissection was unexpectedly observed in PCK rats, which was due to modifications in the elastic architecture of the aorta in combination with the induced hypertension. Interestingly, IAs developed faster in PCK rats compared to WT rats. Variations in the anatomy of the circle of Willis were identified in PCK rats and PKD patients, a risk factor that may (in part) explain the higher IA incidence found in these groups. At 2 weeks after induction, the endothelium of IAs from PCK rats showed a decrease in the tight junction proteins zonula occludens-1 and claudin-5. Furthermore, the Type III collagen content was lower in IAs of PCK rats at 4 weeks post-surgery. The decrease in tight junction proteins was also observed in the endothelium of human ruptured IAs compared to unruptured IAs.

conclusionOur study showed that PCK rats are more sensitive to IA induction. Variations in the anatomy of the circle of Willis and impaired regulation of tight junction proteins might put PCK rats and PKD patients more at risk of developing vulnerable IAs.

Indexed as

Aneurysm, RupturedAortic DissectionCircle of WillisIntracranial AneurysmPolycystic Kidney DiseasesAnimalsDisease Models, AnimalFemaleHumansMaleMiddle AgedRatsRisk FactorsTime FactorsCircle of WillisIntracranial aneurysmPolycystic kidney diseaseRatsTight junctions

Identifiers

PMID40249101
PMCPMC12160838

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.