Evidence map›Paper›PMID 40249098›Full record

Trial reportPain medicine (Malden, Mass.)2025

Design and implementation of online acceptance and commitment therapy with enhanced therapist support for chronic low back pain (ACT for PAIN).

Sara Jones Berkeley, Sharlene Wedin, Seema M Patidar, Skye O Margolies, Amy M Goetzinger, Matthew C Mauck, Ajay D Wasan, Lance M McCracken

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain medicine (Malden, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05396014 (The BEST Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05396014 phase4completednot on this map

The BEST Trial: Biomarkers for Evaluating Spine Treatments

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2024Enrolled1,014ConditionsChronic Low-back PainArmsEnhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM), Duloxetine
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara Jones BerkeleyDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.ORCID 0009-0001-1041-5715
Sharlene WedinDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, United States.
Seema M PatidarDepartment of Anesthesiology, UNC School of Medicine, Chapel Hill, NC 27514, United States.
Skye O MargoliesDepartment of Anesthesiology, UNC School of Medicine, Chapel Hill, NC 27514, United States.
Amy M GoetzingerDepartment of Anesthesiology, UNC School of Medicine, Chapel Hill, NC 27514, United States.
Matthew C MauckDepartment of Anesthesiology, UNC School of Medicine, Chapel Hill, NC 27514, United States.
Ajay D WasanDepartments of Anesthesiology & Perioperative Medicine, and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States.ORCID 0000-0002-6394-6077
Lance M McCrackenPsychology Department, Uppsala University, Uppsala 751 42, Sweden.ORCID 0000-0002-9734-0153

Funding

Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management CenterU24AR076730 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANSTROM, KEVIN J, IVANOVA, ANASTASIA · 2019 to 2024
$60.0M
HEALNIAMS NIH HHS U24 AR076730NIH HHS 1U24AR076730
6 · The paper itself

Abstract

backgroundChronic low back pain (cLBP) typically involves behavior patterns in the development and maintenance of symptoms. Acceptance and Commitment Therapy (ACT) is an evidence-based treatment for chronic pain shown to improve pain-related depression, anxiety, and sleep, as well as pain catastrophizing, pain interference, and levels of reported pain. It has been proven effective when delivered in person or online, but an online therapist-enhanced ACT has not been tested to treat cLBP. This approach may have care delivery advantages while maintaining patient engagement with treatment.

objectiveDescribe the design and implementation of the therapist-supported, online model of ACT that was evaluated in the Biomarking for Evaluating Spine Treatments (BEST) Trial.

methodsThe BEST Trial is a sequential, multiple assignment randomized trial of 4 treatment modalities (exercise and manual therapy; duloxetine; enhanced self-management of pain; and ACT) to inform a precision medicine approach to the treatment of cLBP. The ACT intervention was delivered over the internet via a custom, web-based software platform. The program had three primary components: (1) interactive online sessions consisting of video, audio and self-assessment; (2) therapist sessions via video visits; and (3) ongoing therapist support outside the video visits through a messaging system. DISCUSSION: The ACT intervention addresses the need for mental health care integrated with chronic low back pain treatment. The online ACT treatment program with enhanced therapist support was designed to overcome barriers to multimodal care of CLBP and improve a range of treatment outcomes. CLINICALTRIAL.GOV ID: NCT05396014. REGISTRATION: The BEST Trial is registered in ClinicalTrials.gov (NCT05396014): https://clinicaltrials.gov/study/NCT05396014.

Indexed as

Acceptance and Commitment TherapyChronic PainLow Back PainPain ManagementAdultDuloxetine HydrochlorideFemaleHumansInternetMaleDuloxetine HydrochlorideAcceptance and Commitment Therapychronic paintelehealth

Identifiers

PMID40249098
PMCPMC12314360

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.