Evidence map›Paper›PMID 40249077›Full record

ArticleEuropean journal of immunology2025

Combined Deletion of ZFP36L1 and ZFP36L2 Drives Superior Cytokine Production in T Cells at the Cost of Cell Fitness.

Nordin D Zandhuis, Antonia Bradarić, Carmen van der Zwaan, Arie J Hoogendijk, Branka Popović, Monika C Wolkers

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nordin D ZandhuisDepartment of Research, T Cell Differentiation Lab, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.
Antonia BradarićDepartment of Research, T Cell Differentiation Lab, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.
Carmen van der ZwaanAmsterdam UMC Landsteiner Laboratory University of Amsterdam Cancer Center Amsterdam Cancer Immunology, and Amsterdam Institute for Infection & Immunity, Amsterdam, The Netherlands.
Arie J HoogendijkAmsterdam UMC Landsteiner Laboratory University of Amsterdam Cancer Center Amsterdam Cancer Immunology, and Amsterdam Institute for Infection & Immunity, Amsterdam, The Netherlands.
Branka PopovićDepartment of Research, T Cell Differentiation Lab, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.
Monika C WolkersDepartment of Research, T Cell Differentiation Lab, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.ORCID 0000-0003-3242-1363

Funding

European Research Council PRINTERS 817533Landsteiner Foundation for Blood Transfusion Research 2103
6 · The paper itself

Abstract

A key feature of cytotoxic CD8

Indexed as

Butyrate Response Factor 1CD8-Positive T-LymphocytesCytokinesTristetraprolinAnimalsInterferon-gammaLymphocyte ActivationLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLMice, KnockoutTumor Necrosis Factor-alphaButyrate Response Factor 1CytokinesInterferon-gammaTristetraprolinTumor Necrosis Factor-alphaZfp36l1 protein, mouse

Identifiers

PMID40249077
PMCPMC12007392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.