Evidence map›Paper›PMID 40248938›Full record

ArticleCurrent medical imaging2025

The Impact of Therapeutic Ultrasound on Bone Radio Density Following Orthodontic Treatment with Clear Aligners: A Preliminary Study

Mohsen Gholizadeh, Hollis Lai, Lindsey Westover, Tarek El-Bialy

Abstract read
In one paragraph

Article in Current medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohsen GholizadehFaculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0009-0004-9138-1677
Hollis LaiDepartment of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-5531-6622
Lindsey WestoverDepartment of Mechanical Engineering Associate Dean (Graduate Students), Department of Biomedical Engineering, University of Alberta, Edmonton, Canada.ORCID 0000-0003-1220-3967
Tarek El-BialyDepartment of Dentistry, Division of Orthodontics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-4435-5172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study evaluated the impact of Low-Intensity Pulsed Ultrasound (LIPUS) on bone radio density in patients undergoing orthodontic treatment with clear aligners, aiming to enhance bone remodeling and improve treatment stability.

methodsThis retrospective study included 68 participants divided into two groups: 34 treated with LIPUS and 34 in a control group. Bone radio density was measured using Hounsfield units from CBCT scans before and after treatment. Statistical analyses included Mann-Whitney U tests and paired ttests.

resultsThe average age was 29.85 ± 14.85 years in the control group and 36.29 ± 12.78 years in the LIPUS group. Bone radio density in the upper arch of the LIPUS group significantly increased from 444.6 HU to 751.3 HU (p < 0.001), while the control group showed a slight decrease in the upper arch (657.4 HU to 650.5 HU, p = 0.86). In the lower arch, a similar trend was observed in the LIPUS group, with an increase from 767.7 HU to 823.4 HU (p = 0.17), though not statistically significant. There were no significant differences in post-treatment ABO DI scores between groups, suggesting equivalent effectiveness in achieving orthodontic outcomes.

conclusionLIPUS with clear aligners seems promising in enhancing bone radio density, indicating an improved bone remodeling effect. This highlights LIPUS's potential as a beneficial adjunct in orthodontic treatments.

Indexed as

Bone DensityUltrasonic TherapyAdolescentAdultBone RemodelingCone-Beam Computed TomographyFemaleHumansMaleRetrospective StudiesYoung AdultBone Radio DensityCBCTCBCT.Clear AlignersHounsfield UnitsLow-Intensity Pulsed Ultrasound (LIPUS)Orthodontic outcomes

Identifiers

PMID40248938
PMCPMC12784381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.