Evidence map›Paper›PMID 40248897›Full record

ArticleOncoimmunology2025

Targeting the atypical chemokine receptor 2 (

Muhammad Zaeem Noman, Martyna Szpakowska, Malina Xiao, Ruize Gao, Kris Van Moer, Akinchan Kumar, Markus Ollert, Guy Berchem, Andy Chevigné, Bassam Janji

Abstract read
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad Zaeem NomanTumor Immunotherapy and Microenvironment (TIME), Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.
Martyna SzpakowskaImmuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-5659-8377
Malina XiaoTumor Immunotherapy and Microenvironment (TIME), Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.
Ruize GaoTumor Immunotherapy and Microenvironment (TIME), Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.
Kris Van MoerTumor Immunotherapy and Microenvironment (TIME), Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.
Akinchan KumarTumor Immunotherapy and Microenvironment (TIME), Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.
Markus OllertImmuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Guy BerchemTumor Immunotherapy and Microenvironment (TIME), Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.
Andy ChevignéImmuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID 0000-0003-4768-6743
Bassam JanjiTumor Immunotherapy and Microenvironment (TIME), Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.ORCID 0000-0002-9763-0943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint blockade (ICB) therapies, such as anti-PD-1, have transformed cancer treatment, but many patients do not respond due to a non-inflammatory tumor microenvironment (TME). Here, we investigated the impact of targeting Atypical Chemokine Receptor 2 (

Indexed as

Immune Checkpoint InhibitorsMelanomaMelanoma, ExperimentalProgrammed Cell Death 1 ReceptorReceptors, CCRAnimalsCD8-Positive T-LymphocytesCell Line, TumorChemokine CCL5Chemokine CXCL10Disease Models, AnimalFemaleHumansImmunotherapyKiller Cells, NaturalMiceChemokine CCL5Chemokine CXCL10Immune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorReceptors, CCRACKR2anti-PD-1Cancer immunotherapyCCL5combination immunotherapyD6immune cell infiltrationimmune checkpoint blockadeinflammatory chemokinesmelanomascavenger receptortumor microenvironment

Identifiers

PMID40248897
PMCPMC12013441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.