Evidence map›Paper›PMID 40248855›Full record

ArticleProtein science : a publication of the Protein Society2025

Nonlinear optical properties of photosensory core modules of monomeric and dimeric bacterial phytochromes.

Diana Galiakhmetova, Aleksandr Koviarov, Viktor Dremin, Tatjana Gric, Dmitrii Stoliarov, Andrei Gorodetsky, Marios Maimaris, Daria M Shcherbakova, Mikhail Baloban, Vladislav V Verkhusha and 2 more

Abstract read
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In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Diana GaliakhmetovaAston Institute of Photonic Technologies, Aston University, Birmingham, UK.ORCID 0000-0002-6222-2122
Aleksandr KoviarovAston Institute of Photonic Technologies, Aston University, Birmingham, UK.
Viktor DreminAston Institute of Photonic Technologies, Aston University, Birmingham, UK.
Tatjana GricDepartment of Electronic Systems, Vilnius Gediminas Technical University, Vilnius, Lithuania.
Dmitrii StoliarovAston Institute of Photonic Technologies, Aston University, Birmingham, UK.
Andrei GorodetskySchool of Physics and Astronomy, University of Birmingham, Birmingham, UK.
Marios MaimarisUltrafast Optoelectronics Group, Imperial College London, London, UK.
Daria M ShcherbakovaDepartment of Genetics and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Mikhail BalobanDepartment of Genetics and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0003-3919-1222
Vladislav V VerkhushaDepartment of Genetics and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-2083-8121
Sergei G SokolovskiAston Institute of Photonic Technologies, Aston University, Birmingham, UK.
Edik RafailovAston Institute of Photonic Technologies, Aston University, Birmingham, UK.

Funding

Near-Infrared Fluorescent Proteins, Biosensors and Optogenetic ToolsR35GM122567 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Vladislav Verkhusha · 2017 to 2026
$4.3M
Engineering and Physical Sciences Research Council EP/W002868/1European Cooperation in Science and Technology CA23125H2020 Research and Innovation Programme 863214NIGMS NIH HHS R35 GM122567US National Institutes of Health GM122567
6 · The paper itself

Abstract

Near-infrared (NIR) fluorescent proteins and optogenetic tools derived from bacterial phytochromes' photosensory core modules (PCMs) operate within the first (NIR-I) tissue transparency window under single-photon activation. Leveraging two-photon (2P) light in the second transparency window (NIR-II) for photoswitching bacterial phytochromes between Pr and Pfr absorption states offers significant advantages, including enhanced tissue penetration, spatial resolution, and signal-to-noise ratio. However, 2P photoconversion of bacterial phytochromes remains understudied. Here, we study the non-linear Pr to Pfr photoconversion's dependence on irradiation wavelength (1180-1360 nm) and energy fluence (41-339 mJ/cm

Indexed as

Bacterial ProteinsPhytochromeProtein MultimerizationBacterial ProteinsPhytochromebacterial phytochromeDrBphPlong‐wavelength excitationNear‐infrared fluorescent protein (iRFP)two‐photon photoconversion

Identifiers

PMID40248855
PMCPMC12006755

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.