ArticleCase reports in ophthalmology
Topical Losartan Treatment of Herpes Simplex Virus- or Varicella-Zoster Virus-Induced Corneal Scarring: A Case Series.
Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Topical losartan to prevent stromal scarring during post-cross-linking infection in pediatric keratoconus: A case report.American journal of ophthalmology case reports · 2026Article
- Topical Losartan in Ophthalmology: Rationale, Experimental and Clinical Evidence, and Emerging Clinical Applications.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Topical losartan has emerged as a promising therapeutic option for preventing and treating corneal scarring fibrosis. Its mechanism of action involves the inhibition of ERK-mediated signaling in the noncanonical TGF-beta pathways, promoting apoptosis of myofibroblasts and facilitating a return of corneal transparency. While numerous studies in rabbits and several human case reports have demonstrated its efficacy and safety, published data on its use in clinical scenarios remain limited. This study presents 3 cases where topical losartan successfully treated corneal scarring induced by herpes simplex virus (HSV) or varicella-zoster virus (VZV) keratitis. Case Presentations: Three patients (ages 40, 38, 15 years) with corneal scarring and vision loss from HSV or VZV keratitis were treated with topical 0.8 mg/mL losartan 6 times a day for 4-9 months, depending on the clinical response, after failing traditional management with corticosteroids. Best spectacle-corrected vision and slit-lamp corneal opacity improved in each case. Anterior segment OCT documented improved stromal opacity in 1 case. Conclusions: Topical losartan, a known inhibitor of fibrotic TGF-beta signaling, is potentially an effective alternative in the treatment of stromal scarring fibrosis caused by corneal HSV and VZV infections. Patients with HSV- or VZV keratitis-induced corneal scarring may be ideal candidates for planned clinical trials of the efficacy and safety of topical losartan treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.