ArticleNeuropsychiatric disease and treatment2025
The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Complex correlations between mitochondrial DNA variants and gut microbiome in major depressive disorder: a genome-wide association analysis.BMC psychiatry · 2026Article
- Neuroimaging evidence of mitochondrial dysfunction and inflammation in psychiatric disorders: a review.Psychoradiology · 2026Review
- Decoding nuclear-encoded mitochondrial genes in major depressive disorder: A multi-omics perspective.Psychological medicine · 2025Article
- The Presence of the mtDNA4977 Deletion Does Not Necessarily Mean That It is Responsible for Major Depression [Letter].Neuropsychiatric disease and treatment · 2025Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Major depressive disorder (MDD) is significantly influenced by genetic factors. The present study aims to examine the potential correlation between the 4977 bp deletion of mitochondrial DNA (mtDNA) and MDD. Methods: The 4977 bp deletion of mtDNA was detected in the peripheral blood of 253 MDD patients and 257 healthy controls, with depression assessed by the Hamilton Depression Rating scale and functioning by the Global Assessment of Function Scale. Results: MDD patients had a higher incidence of the 4977 bp deletion, unaffected by demographic or clinical factors. Conclusion: The 4977 bp deletion may be a trait marker for MDD.
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