Evidence map›Paper›PMID 40248719›Full record

ArticleTranslational lung cancer research2025

Enhancing the precision of auxiliary diagnosis for lung cancer through use of

Ping Gu, Yue Wang, Chunlei Shi, Yuqing Chen, Jialin Qian, Yanjie Niu, Hai Zhang, Yunxia Bao, Bin She, Xiaosha Ren and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Clinical value of combinedOncology reviews · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ping Gu *Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yue Wang *Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chunlei ShiDepartment of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuqing ChenDepartment of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jialin QianDepartment of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanjie NiuDepartment of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hai ZhangDepartment of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yunxia BaoDepartment of Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bin SheDepartment of Academic Development, Shanghai Methyldia Technology Co., Ltd., Shanghai, China.
Xiaosha RenDepartment of Academic Development, Shanghai Methyldia Technology Co., Ltd., Shanghai, China.
Iyare IzevbayeDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Grady Health System, Atlanta, GA, USA.
Baohui HanDepartment of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hua ZhongDepartment of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu DongDepartment of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Exfoliated cells in biopsy fluid are commonly utilized for cytological testing to complement histological examination. Nevertheless, the sensitivity of cytological testing is relatively low. Therefore, there is an urgent need to identify more sensitive biomarkers that can substitute for cytology and improve the overall diagnostic accuracy of lung cancer biopsies. The study aims to find biomarkers with greater sensitivity to replace cytology and enhance the overall diagnostic accuracy of lung cancer biopsies by evaluating the complementary roles of cytology and methylation in relation to histology. Methods: A cohort of 173 patients, including 127 individuals diagnosed with lung cancer and 46 individuals with benign lesions, was successively recruited from Shanghai Chest Hospital. These patients underwent cell smear, ThinPrep cytologic test (TCT), methylation analysis, and histological examination to assess the complementary roles of cytology and methylation in relation to histology could be evaluated. Results: The cutoff values of Conclusions: The findings suggest that LungMe methylation could replace cytology as an adjunctive diagnostic tool for histology. Moreover, a positive methylation test result could indicate a potential malignancy, necessitating further confirmation by the hospital and thereby reducing the likelihood of missed diagnoses.

Indexed as

biopsy liquidlung cancermethylationRASSF1ASHOX2

Identifiers

PMID40248719
PMCPMC12000937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.