ArticleAdvanced nanobiomed research2024
Laponite nanoclay loaded microgel suspensions as supportive matrices for osteogenesis.
Article in Advanced nanobiomed research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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3 authors.
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Abstract
Microscale carriers have emerged as promising materials for nurturing cell growth and as delivery vehicles for regenerative therapies. Carriers based on hydrogels have proved advantageous, where "microgels" can be formulated to have a broad range of properties to guide the behavior of adherent cells. Here we demonstrate the fabrication of osteogenic microgels through incorporation of laponite nanoclays. Forming a jammed suspension provides a scaffolding where cells can adhere to the surface of the microgels, with pathways for migration and proliferation fostered by the interstitial volume. By varying the content and type of laponite-RD and XLG-the degree of osteogenesis can be tuned in embedded populations of adipose derived stem cells (ADSCs). The nano- micro-structured composite materials enhance osteogenesis at the transcript and protein level, leading to increased deposition of bone minerals and an increase in the compressive modulus of the assembled scaffold. Together, these microgel suspensions are promising materials for encouraging osteogenesis with scope for delivery via syringe injection and stabilization to bone-mimetic mechanical properties after matrix deposition.
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