ArticleCureus2025
The Importance of Systemic Inflammatory Response Syndrome in Diagnosing Occult Infections: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic inflammatory response syndrome (SIRS) criteria are among the several screening tools for sepsis. While SIRS has been widely utilized in clinical practice, its reliability and construct validity have come under scrutiny in recent years. Research has established that the quick Sequential Organ Failure Score (qSOFA) and Sequential Organ Failure Assessment (SOFA) criteria serve as better predictors of sepsis-related outcomes. We report a case of a patient who was admitted for diabetic ketoacidosis and atrial fibrillation. Despite being afebrile with stable white blood cell counts, he met SIRS criteria (tachycardic and tachypneic) on admission, which initiated an infectious workup. Subsequent investigations revealed multiple substernal and intramuscular abscesses along with costosternal osteomyelitis resulting in methicillin-resistant staphylococcus aureus (MRSA) bacteremia. The patient underwent surgical source control and recovered after a prolonged course of intravenous antibiotics. This study highlights the importance of timely detection of sepsis and the role of SIRS criteria as a reliable screening tool in this process. Notwithstanding the controversy around the credibility of the SIRS criteria, conceptualized nearly two decades ago, it has proven to have greater sensitivity in the initial diagnosis of sepsis in comparison to other available screening tools. Screening for sepsis using both qSOFA and SIRS criteria concurrently, with an understanding of their limitations, represents best practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.