Evidence map›Paper›PMID 40248484›Full record

ArticleSynthetic and systems biotechnology2025

iCASRED, a scarless DNA editing tool in

Guosong Zheng, Jiafeng Xu, Hewei Liu, Huimin Hua, Andrei A Zimin, Wenfang Wang, Yinhua Lu

Abstract read
In one paragraph

Article in Synthetic and systems biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Multi-Targeting Non-Specific Genome Engineering in Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guosong ZhengCollege of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Jiafeng XuCollege of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Hewei LiuCollege of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Huimin HuaCollege of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Andrei A ZiminG.K. Scriabin Institute of Biochemistry and Physiology of Microorganisms RAS, Pushchino, 142290, Russia.
Wenfang WangCollege of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Yinhua LuCollege of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efficient gene cluster editing tools are one of the key techniques for discovering novel compounds encoded by silent natural product (NP) biosynthetic gene clusters (BGCs) in microbial genomes. Currently,

Indexed as

Actinomycete-derived natural productsCRISPR-Cas9E. coliScarless gene cluster editing

Identifiers

PMID40248484
PMCPMC12002714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.