Evidence map›Paper›PMID 40248483›Full record

ArticleSynthetic and systems biotechnology2025

Optimized dual-AAV base editor delivery system with enhanced editing efficiency and virion production titer.

Wenjia Yu, Yujie Wang, Siwei Li, Yingcai Dai, Yucheng Li, Xinyue Zhang, Bo Li, Siriguleng Qian, Xueli Zhang, Changhao Bi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. International journal of biological sciences · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenjia YuSchool of Biological Engineering, Dalian Polytechnic University, Dalian, China.
Yujie WangBinzhou Medical University, Shandong, China.
Siwei LiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300000, China.
Yingcai DaiShanghai Jiao Tong University, Shanghai, China.
Yucheng LiTianjin University of Science and Technology, Tianjin, China.
Xinyue ZhangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300000, China.
Bo LiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300000, China.
Siriguleng QianSchool of Biological Engineering, Dalian Polytechnic University, Dalian, China.
Xueli ZhangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300000, China.
Changhao BiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Base editors (BEs) are a promising tool for precise base conversion in human cells and animals, while the adeno-associated virus (AAV) is the major vector for human gene therapy. However, the size of the DNA cassette required for BE expression exceeds the 4.7 kb packing capacity of the AAV vector, making dual-AAV approaches based on

Indexed as

AAV production titerAdeno-associated virus (AAV)Base editors (BEs)Cas9 split siteDual-AAV systemsTrans-splicing

Identifiers

PMID40248483
PMCPMC12002711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.