Evidence map›Paper›PMID 40248444›Full record

ArticleAdvanced functional materials2024

Biomolecular Neuristors from Functionalized Lipid Membranes.

Michelle Makhoul Mansour, Joshua J Maraj, Robert Jordan Pyron, Francisco N Barrera, Stephen A Sarles

Abstract read
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michelle Makhoul MansourDepartment of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, 37996, TN, USA.
Joshua J MarajDepartment of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, 37996, TN, USA.
Robert Jordan PyronDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville,37996, TN USA.
Francisco N BarreraDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville,37996, TN USA.
Stephen A SarlesDepartment of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, 37996, TN, USA.

Funding

Mechanisms of modulation of transmembrane interactionsR35GM140846 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI BARRERA, FRANCISCO NICOLAS · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM140846
6 · The paper itself

Abstract

Modeled after biological neurons, neuristors are emerging hardware that generate recurring voltage spikes in response to electrical stimulation. This type of excitability could enable transistor-free spiking neural networks for efficient signal processing and computing. Yet, prior neuristors consist of circuits containing numerous devices, thus complicating fabrication and increasing size, power usage, and cost. In contrast, we show that a single, 5nm-thick lipid membrane functionalized with voltage-activated peptides functions as a two-terminal, ultra-low power (fW-pW) artificial neuristor in response to supplied current. Specifically, the biomolecular membrane generates stochastic voltage oscillations (10-150 mV) in response to DC currents (|5-40| pA), and is capable of generating two distinct types of action potentials -

Indexed as

action potentialsBiomolecular neuristorion channelslipid membranevoltage spiking

Identifiers

PMID40248444
PMCPMC12002549

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.