ArticleAmerican journal of preventive cardiology2025
LDL cholesterol burden in elderly patients with familial hypercholesterolemia: Insights from real-world data.
Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Underweight in Young Adult Women as a Dynamic Nutritional State: Evidence from Four Complementary Longitudinal Methods.Nutrients · 2026Article
- Low-density lipoprotein cholesterol longitudinal trajectories and clinical outcomes following an acute coronary syndrome.American journal of preventive cardiology · 2026Article
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Authors and funding
10 authors.
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Abstract
Background and aims: Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) and increased risk of premature coronary heart disease (CHD). While current LDL-C levels usually guides therapy, the cumulative exposure to LDL-C (the LDL-C burden) is suggested to offer a more precise estimate of cardiovascular risk in people with FH. Therefore, using real-world data, this study aimed to estimate the LDL-C burden at different ages in elderly FH patients with and without CHD, and to assess the LDL-C burden at CHD onset. Methods: Data was retrospectively collected from the medical records of elderly (>60 years) FH patients at the Lipid Clinic in Oslo. The LDL-C burden (mM-years) was estimated based on repeated LDL-C measurements and information on lipid-lowering medication. Time-weighted average (TWA) LDL-C was calculated as LDL-C burden divided by years. Results: We included 112 FH patients, of which 55 (49 %) had experienced at least one CHD-event, and 58 (52 %) were females. Median age at first and last visit were 50 years and 68 years, respectively, with a median of 9 (range; 2-14) available LDL-C measurements. Subjects with CHD had higher LDL-C burden at all ages tested (45, 50 and 60 years) compared with the non-CHD group ( Conclusion: Elderly FH patients with CHD had higher estimated LDL-C burden compared with FH patients without CHD, due to higher burden
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