Evidence map›Paper›PMID 40248422›Full record

ArticleFrontiers in oral health2025

Emerging oral

Natalie K Anselmi, Stephen T Vanyo, Michelle B Visser

Abstract read
In one paragraph

Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalie K AnselmiDepartment of Oral Biology, The State University of New York at Buffalo, Buffalo, NY, United States.
Stephen T VanyoDepartment of Oral Biology, The State University of New York at Buffalo, Buffalo, NY, United States.
Michelle B VisserDepartment of Oral Biology, The State University of New York at Buffalo, Buffalo, NY, United States.

Funding

Advanced Training in Oral BiologyT32DE023526 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Stefan Hans-Klaus Ruhl · 2013 to 2026
$3.7M
The role of oral spirochete virulence factors in the impairment of neutrophil responseR01DE027073 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI VISSER, MICHELLE B · 2018 to 2023
$2.0M
Outer Membrane Proteins of Pathogenic Oral Treponemes Inhibit Actin Rearrangement and Antimicrobial Functions of NeutrophilsF31DE030705 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ANSELMI, NATALIE · 2021 to 2023
$98k
NIDCR NIH HHS F31 DE030705NIDCR NIH HHS R01 DE027073NIDCR NIH HHS T32 DE023526
6 · The paper itself

Abstract

Background: Periodontitis (PD) is a group of inflammatory pathologies characterized by destruction of the tooth-supporting tissues. During PD, dysbiosis of the oral biofilm disrupts the host immune response and supports growth of pathogenic bacteria including the spirochetes Methods: This study examines putative mechanisms by which Results: MspA and MspTL increase phosphate release in neutrophils, but unlike Msp, they do not affect PTEN or SHIP activity, despite modulating cellular levels of multiple PIP species [PI(3,4)P Conclusions: Understanding distinct mechanistic relationships between novel Msp proteins and neutrophils provides important insight into how these understudied bacteria promote periodontitis progression.

Indexed as

actinneutrophilperiodontitisphosphoinositideTreponema

Identifiers

PMID40248422
PMCPMC12003349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.