Assessment of the placental microbiota of preterm infants with pneumonia: a case control study.

Lei Zhang, Zijin Chen, Shuai Hu, Hong Liu, Fan Lai, Yinghong Fan, Min Li, Ling Zhou

Abstract read

In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Multi-omics approaches for image classification in disease diagnosis.Frontiers in cellular and infection microbiology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lei Zhang *Department of Pediatric Pulmonology, The Affiliated Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Zijin Chen *Department of Pediatric Pulmonology, The Affiliated Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Shuai HuDepartment of Pediatric Pulmonology, The Affiliated Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Hong LiuDepartment of Operating Room, The Affiliated Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Fan LaiObstetrics and Gynecology Department, The Affiliated Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Yinghong FanDepartment of Pediatric Pulmonology, The Affiliated Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Min LiDepartment of Neonatology, The Affiliated Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Ling ZhouDepartment of Operating Room, The Affiliated Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the specific characteristics and differences in the placental microbiome of preterm infants with and without pneumonia. Methods: Fifty-nine infants born at 32-36 weeks' gestation were enrolled in this study. Among them, 33 developed pneumonia within 48 hours of birth, while the remaining 26 did not. Placental swabs were collected at birth for DNA extraction, from which the placental microbial composition was analyzed using a bioinformatics pipeline following PCR amplification of genetic material and subsequent sequencing of bacterial 16S rRNA. Results: Significant differences in both the alpha and beta diversities were found between the two groups (P<0.05). Conclusion: Overall, this study suggests that alterations in the placental microbiome may be linked to the onset of pneumonia in preterm infants. Further investigations are required to elucidate the relationship between microbiota and disease pathogenesis.

Indexed as

BacteriaInfant, PrematureMicrobiotaPlacentaPneumoniaCase-Control StudiesDNA, BacterialDNA, RibosomalFemaleHumansInfant, NewbornMalePregnancyRNA, Ribosomal, 16SSequence Analysis, DNADNA, BacterialDNA, RibosomalRNA, Ribosomal, 16S16S rRNAmicrobiotaplacentalpneumoniapreterm infants

Identifiers

PMID40248365

DOI10.3389/fcimb.2025.1511141

PMCPMC12004234

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.