Evidence map›Paper›PMID 40248364›Full record

ReviewFrontiers in cellular and infection microbiology2025

Phospholipid scramblase 1: a frontline defense against viral infections.

Alina X Yang, Carmelissa Norbrun, Parand Sorkhdini, Yang Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. METTL7A-Dependent mMedComm · 2026
    Article
  2. Article
  3. IFN-inducible human phospholipid scramblase 1 (PLSCR1) protein restricts HIV-1 infection by inhibiting membrane fusion.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alina X YangDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, United States.
Carmelissa NorbrunDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, United States.
Parand SorkhdiniDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, United States.
Yang ZhouDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, United States.

Funding

Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI SCHMID, CHRISTOPHER H. · 2016 to 2025
$45.0M
Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Brown Respiratory Research Training ProgramT32HL134625 · NHLBI · BROWN UNIVERSITY · PI Elizabeth O Harrington, Sharon Irene Smith Rounds · 2017 to 2026
$5.1M
Targeting CHI3L and its receptors in Hermansky-Pudlak Syndrome-associated lung diseaseR01HL146498 · NHLBI · BROWN UNIVERSITY · PI ZHOU, YANG · 2020 to 2024
$2.2M
American Heart Association-American Stroke Association 24TPA1277918NHLBI NIH HHS R01 HL146498NHLBI NIH HHS T32 HL134625NIGMS NIH HHS P20 GM103652NIGMS NIH HHS U54 GM115677
6 · The paper itself

Abstract

Phospholipid scramblase 1 (PLSCR1) is the most studied member of the phospholipid scramblase protein family. Its main function is to catalyze calcium (Ca

Indexed as

Phospholipid Transfer ProteinsVirus DiseasesAnimalsAntiviral AgentsHumansInterferonsSARS-CoV-2Signal TransductionVirusesVirus ReplicationAntiviral AgentsInterferonsPhospholipid Transfer ProteinsPLSCR1 protein, humanantiviralEpstein-Barr virusHBV - hepatitis B virusHCMV (human cytomegalovirus)HIVinfluenza A virusPLSCR1SARS-CoV-2

Identifiers

PMID40248364
PMCPMC12003403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.