Evidence map›Paper›PMID 40248351›Full record

ReviewFrontiers in cell and developmental biology2025

Effects of particulate air pollution exposure on lung-brain axis and related miRNAs modulation in mouse models.

Alessandro Giammona, Giulia Terribile, Paolo Rainone, Chiara Pellizzer, Danilo Porro, Antonio Cerasa, Giulio Sancini, Ameen-Ur Rashid, Sara Belloli, Silvia Valtorta and 2 more

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alessandro Giammona *Istituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC), National Research Council (CNR), Segrate, Italy.
Giulia Terribile *Human Physiology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Paolo Rainone *Istituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC), National Research Council (CNR), Segrate, Italy.
Chiara PellizzerIstituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC), National Research Council (CNR), Segrate, Italy.
Danilo PorroPhD Program, Program in Neuroscience, Medicine and Surgery Department, University of Milano-Bicocca, Milano, Italy.
Antonio CerasaIstituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC), National Research Council (CNR), Segrate, Italy.
Giulio SanciniHuman Physiology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Ameen-Ur RashidNeuroMI - Milan Centre for Neuroscience, University of Milano-Bicocca, Milano, Italy.
Sara BelloliIstituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC), National Research Council (CNR), Segrate, Italy.
Silvia ValtortaIstituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC), National Research Council (CNR), Segrate, Italy.
Alessia Lo Dico *Istituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC), National Research Council (CNR), Segrate, Italy.
Gloria Bertoli *Istituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC), National Research Council (CNR), Segrate, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Particulate matter exposure is linked to numerous health issues, including respiratory, cardiovascular, and neurodegenerative diseases. This review focuses on the biological mechanisms through which air pollution influences the lung-brain axis, highlighting the role of miRNAs in regulating gene pathways affected by PM. Some microRNAs (miRNAs) are identified as key modulators of cellular processes, including inflammation, epithelial-to-mesenchymal transition (EMT), and blood-brain barrier integrity. Using mice models to study these effects allows for controlled experimentation on the systemic distribution of PM across biological barriers. Among the imaging technologies, Positron Emission Tomography is the best approach to monitor the distribution and effects of PM

Indexed as

air pollutioncancer and imaginglung-brain axismicemiRNA

Identifiers

PMID40248351
PMCPMC12003928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.