Evidence map›Paper›PMID 40248027›Full record

ArticleIn silico pharmacology2025

GABAergic antidepressant effect of daidzin: in vivo approach with in silico receptor binding affinities.

Md Torequl Islam, Md Showkot Akbor, Md Shimul Bhuia, Rubel Hasan, Raihan Chowdhury, Md Amirul Islam, Md Saifuzzaman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In silico pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Md Torequl IslamPharmacy Discipline, Khulna University, Khulna, 9208 Bangladesh.
Md Showkot AkborDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100 Bangladesh.
Md Shimul BhuiaDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100 Bangladesh.
Rubel HasanDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100 Bangladesh.
Raihan ChowdhuryDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100 Bangladesh.
Md Amirul IslamPharmacy Discipline, Khulna University, Khulna, 9208 Bangladesh.
Md SaifuzzamanPharmacy Discipline, Khulna University, Khulna, 9208 Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Daidzin (DZN: 7-(β-D-Glucopyranosyloxy)-4-hydroxyisoflavone) is a soy plant-derived isoflavone. It has diverse biological activities, including nephroprotective effects. To date, its anxiolytic, memory-enhancing, and antiepileptic properties have been discovered. However, its antidepressant activity has not yet been investigated.This study aimed to investigate DZN's antidepressant activity through animal and in silico studies. Male

Indexed as

Antidepressant effectDaidzinGABAergic interactionModulatory neurological activity

Identifiers

PMID40248027
PMCPMC11999917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.