Evidence map›Paper›PMID 40247884›Full record

ArticleAdvances in drug and alcohol research2025

Chronic alcohol withdrawal-associated increases in VTA

Shealan Cruise, Maria E Secci, Leslie K Kelley, Nathan M Sharfman, Keishla Rodriguez-Graciani, Tiffany A Wills, Nicholas W Gilpin, Elizabeth M Avegno

Abstract read
In one paragraph

Article in Advances in drug and alcohol research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shealan CruiseDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Maria E SecciDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Leslie K KelleyDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Nathan M SharfmanDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Keishla Rodriguez-GracianiDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Tiffany A WillsDepartment of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Nicholas W GilpinDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Elizabeth M AvegnoDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.

Funding

Sex Specific Effects of Adolescent Alcohol Exposure on BNST PlasticityR01AA028011 · NIAAA · LSU HEALTH SCIENCES CENTER · PI WILLS, TIFFANY A · 2021 to 2025
$1.8M
Orexin modulation of brain reward-brain stress system interactions in alcohol withdrawal anxietyK01AA028541 · NIAAA · LSU HEALTH SCIENCES CENTER · PI Elizabeth Minor Avegno · 2022 to 2026
$818k
NIAAA NIH HHS K01 AA028541NIAAA NIH HHS R01 AA028011
6 · The paper itself

Abstract

Alcohol withdrawal is characterized by various symptoms that include pain and negative affect in the absence of the drug. The neural underpinnings of these behaviors are not entirely understood, but orexin has emerged as a candidate target for the treatment of substance use disorders. Here, we explored changes in orexin system-related gene expression in brain regions important for mediating reward and stress, including the ventral tegmental area (VTA) and extended amygdala (including the central amygdala, nucleus accumbens shell, and bed nucleus of the stria terminalis), in adolescent and adult female Wistar rats following chronic alcohol exposure. We observed higher numbers of

Indexed as

alcoholanxiety-like behaviorfemalenociceptionorexinventral tegmental areawithdrawal

Identifiers

PMID40247884
PMCPMC12004375

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.