Evidence map›Paper›PMID 40247843›Full record

ArticlePeerJ2025

Catecholamine exposure and the gut microbiota in obstructive sleep apnea.

Joe Alcock, Dongdong Lin, Prashanth Setty, Lee K Brown, Armand E K Dichosa, Benjamin J Burnett, Cliff S Han, Henry C Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The gut pathobiome: a new frontier in the management of the critically ill.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joe AlcockDepartment of Emergency Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States of America.
Dongdong LinEMD Serono, Inc, Boston, MA, United States of America.
Prashanth SettyApplied Biomedical, Inc, Placentia, CA, United States of America.
Lee K BrownDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
Armand E K DichosaLos Alamos National Laboratory, Los Alamos, NM, United States of America.
Benjamin J BurnettAscent Healthcare, Beaverton, OR, United States of America.
Cliff S HanKnoze Jr, Los Alamos, NM, United States of America.
Henry C LinDivision of Gastroenterology, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with obstructive sleep apnea (OSA) have increased mortality from chronic inflammatory and cardiovascular diseases. Excess catecholamine exposure contributes to the disease associations of OSA, but the underlying mechanism is unknown. This study tested the hypothesis that increased catecholamine exposure is associated with Enterobacteriaceae abundance in OSA. We compared urinary norepinephrine and the fecal microbiota in 24 patients with OSA and 23 controls. Urinary norepinephrine was elevated in OSA patients, consistent with increased sympathetic activation in those patients. OSA patients did not show changes in the community structure of the microbiome or in Enterobacteriaceae abundance compared to controls. Longitudinal changes in Enterobacteriaceae abundance in OSA patients were significantly associated with within-subject changes in norepinephrine, but this association was absent in controls. These results provide a preliminary association between norepinephrine exposure and Enterobacteriaceae in patients with disordered sleep.

Indexed as

CatecholaminesGastrointestinal MicrobiomeNorepinephrineSleep Apnea, ObstructiveAdultCase-Control StudiesEnterobacteriaceaeFecesFemaleHumansMaleMiddle AgedCatecholaminesNorepinephrineCircadian rhythmMicrobiomeNorepinephrineObstructive sleep apneaSleep disorderSympathetic nervous system

Identifiers

PMID40247843
PMCPMC12005174

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.