ArticleEndocrine, metabolic & immune disorders drug targets2026
Identification of Hub Neutrophil Coexpressed Genes in Acute Pancreatitis
Article in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundAcute pancreatitis (AP) is a disease with high morbidity and mortality. Neutrophils are highly correlated with the occurrence and severity of the inflammatory response in AP. However, the mechanism by which neutrophils act on AP is currently unclear. We aimed to target genes coexpressed with neutrophils to identify new possibilities for diagnosing and treating AP.
methodsWe analyzed the differences in immune infiltration in AP and the differential expression of neutrophil-coexpressed genes. Then, models were built through various machine learning methods, and the hub neutrophil coexpressed genes were identified. Receiver operating characteristic (ROC) curves were used for validation, and the relationships between the hub neutrophil coexpressed genes and immune infiltration were explored. GSEA and GSVA were used to investigate the biological functions of genes. Finally, we explored the miRNAs and lncRNAs associated with the hub neutrophil coexpressed genes.
resultsNeutrophil infiltration varied significantly in samples from patients with AP.
conclusionsIn this study, genes coexpressed with neutrophils in AP were identified, and their biological functions were investigated. These findings may provide more effective therapeutic strategies for the prediction, prevention, and personalized treatment of patients with AP.
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