Evidence map›Paper›PMID 40247806›Full record

ReviewCurrent diabetes reviews2026

An Insight on Flavonoids and Flavonoidsincorporated Nano-formulations in the Management of Diabetes Mellitus.

Madhavi Patel, Priya Shah, Sudarshan Singh, Bhupendra G Prajapati

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current diabetes reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madhavi PatelParul Institute of Pharmacy, Parul University, Limda, Vadodara, Gujarat, 391760, India.
Priya ShahL.J. Institute of Pharmacy, L.J. University, Sarkhej, Ahmedabad, Gujarat, 382210, India.
Sudarshan SinghFaculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.
Bhupendra G PrajapatiShree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, 384012, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a worldwide health challenge and imposes a considerable strain on healthcare systems. By 2035, it is anticipated that around 592 million adults will be impacted by diabetes as a result of causes like aging, rapid population expansion, urbanization, obesity, lifestyle modifications, and heightened intake of calorie-dense, fatty, and fast meals. Despite the availability of several pharmaceutical therapies, they often come with higher expenses and adverse side effects, making them inaccessible to a large portion of the population. Bioactive compounds, especially flavonoids, are emerging as potential alternatives for diabetes management. Flavonoids, a category of polyphenolic chemicals included in fruits, vegetables, and various plant- derived foods, provide numerous therapeutic advantages. In addition to their glucose-lowering benefits, they increase antioxidant defence, improve insulin efficacy, and diminish the risk of cardiovascular problems. The clinical application of flavonoids is hindered by issues like poor solubility, low bioavailability, and complicated metabolism. This review explores the integration of nanotechnology- based delivery technologies to address these limitations. Advanced nano-formulations, such as polymeric nanoparticles, liposomes, micelles, and solid lipid nanoparticles, improve the solubility, stability, and absorption of flavonoids while facilitating targeted delivery and prolonged therapeutic benefits. The review highlights the efficacy of flavonoid-based nano-formulations in efficiently managing diabetes mellitus and its related problems. Moreover, it highlights the need for ongoing research to enhance these formulations and explore the molecular pathways that underlie their antidiabetic efficacy. This approach demonstrates the significance of nanotechnology in transforming diabetes care and enhancing patient outcomes.

Indexed as

Diabetes MellitusFlavonoidsHypoglycemic AgentsNanoparticlesAnimalsHumansFlavonoidsHypoglycemic AgentsBioactive compoundsdiabetes mellitusflavonoidsnano-formulationsnatural productsolid lipid nanoparticles

Identifiers

PMID40247806

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.