ArticleCurrent drug metabolism2025
Rapid and Comprehensive Identification of Vincosamide Metabolites
Article in Current drug metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
backgroundVincosamide, an indole alkaloid extracted from
objectivesThis study aims to investigate the metabolism of vincosamide both
methodsSamples of liver microsomal incubation, plasma, bile, urine, and feces following vincosamide administration were analyzed by ultra-high performance liquid chromatography-quadrupole-Exactive Orbitraphigh resolution mass spectrometry (UHPLC-Q-Exactive Orbitrap HRMS). The collected data were analyzed using Compound Discovery 3.2 software and the molecular network method. The metabolites identified through these methodologies were subsequently validated using Xcalibur 4.1 software, which provided information on retention times, parent ions, and characteristic fragment ions.
resultsA total of 37 metabolites were identified, including 8
conclusionThis study elucidates the metabolism of vincosamide
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