Evidence map›Paper›PMID 40247725›Full record

ReviewAsian journal of andrology2025

Fresh versus frozen micro-TESE sperm and outcomes.

Krishna Chaitanya Mantravadi, Marlon Martinez, Favian Ariiq Rahmat, Armand Achmadsyah, Missy Savira, Ponco Birowo

Abstract readReviewComparative Study
In one paragraph

Review in Asian journal of andrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Krishna Chaitanya MantravadiDepartment of Clinical Embryology, Oasis Fertility, Hyderabad 500034, India.
Marlon MartinezGlobal Andrology Forum, Moreland Hills, OH 44022, USA.
Favian Ariiq RahmatGlobal Andrology Forum, Moreland Hills, OH 44022, USA.
Armand AchmadsyahGlobal Andrology Forum, Moreland Hills, OH 44022, USA.
Missy SaviraGlobal Andrology Forum, Moreland Hills, OH 44022, USA.
Ponco BirowoGlobal Andrology Forum, Moreland Hills, OH 44022, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractThe use of fresh versus frozen spermatozoa in men with nonobstructive azoospermia (NOA) undergoing in vitro fertilization (IVF) has been a debated hot topic among reproductive specialists. Each approach presents distinct advantages and disadvantages, with fresh sperm typically showing superior sperm quality, while frozen sperm offers logistical flexibility and a reliable backup for repeated cycles. This review summarizes the latest advancements in sperm retrieval and cryopreservation techniques, providing practitioners with a comprehensive analysis of each option's strengths and limitations. Comparative studies indicate that, although fresh sperm often has better quality metrics, cryopreservation methods such as vitrification have significantly improved postthaw outcomes, making frozen sperm a viable choice in assisted reproductive technologies (ART). The findings show comparable rates for fertilization, implantation, clinical pregnancy, and live birth between fresh and frozen microdissection testicular sperm extraction (micro-TESE) sperm in many cases, although patient-specific factors such as timing, cost-effectiveness, and procedural convenience should guide the final decision. Ultimately, the choice of using fresh or frozen sperm should align with the individual needs and conditions of patients. This tailored approach, supported by the latest advancements, can optimize ART outcomes and provide personalized reproductive care.

Indexed as

AzoospermiaCryopreservationSemen PreservationSpermatozoaSperm RetrievalFemaleFertilization in VitroHumansMaleMicrodissectionPregnancyPregnancy Ratecryopreservationinfertilitymicrodissection testicular sperm extractionnonobstructive azoospermiaspermatozoa

Identifiers

PMID40247725
PMCPMC12112934

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.